5-Methoxy-2-(4-MethoxyphenylaMino)benzoic acid

Base Information

• Chemical Name: 5-Methoxy-2-(4-MethoxyphenylaMino)benzoic acid
• CAS No.: 56980-14-4
• Molecular Formula: C15H15NO4
• Molecular Weight: 273.288
• Hs Code.: 2922509090
• Mol file: 56980-14-4.mol

Synonyms:QC-975;2-p-anisidino-5-methoxy-benzoic acid;2-p-Anisidino-5-methoxy-benzoesaeure;

Chemical Property of 5-Methoxy-2-(4-MethoxyphenylaMino)benzoic acid

Chemical Property:

• Vapor Pressure: 8.11E-09mmHg at 25°C
• Melting Point: 173-174 °C
• Boiling Point: 448.2°C at 760 mmHg
• PKA: 3.61±0.36(Predicted)
• Flash Point: 224.9°C
• PSA: 67.79000
• Density: 1.265g/cm³
• LogP: 3.21860

Purity/Quality:

99% ^*data from raw suppliers

6-p-Anisidino-m-anisic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-p-Anisidino-m-anisic Acid, is an intermediate in the synthesis of more complex pharmaceutical and biologically active compounds. It can be used for the construction of photoswitchable macrocycles incorporating acridane moieties.

Technology Process of 5-Methoxy-2-(4-MethoxyphenylaMino)benzoic acid

There total 3 articles about 5-Methoxy-2-(4-MethoxyphenylaMino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-methoxy-aniline (104-94-9) + 2-bromo-5-methoxy-benzoic acid (22921-68-2) → 5-methoxy-2-[(4-methoxyphenyl)amino]benzoic acid (56980-14-4)

Guidance literature:

With copper; potassium carbonate; In pentan-1-ol; at 160 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.6b01240

Reference yield:

C8H9BrO3 + 4-methoxy-aniline (104-94-9) → 5-methoxy-2-[(4-methoxyphenyl)amino]benzoic acid (56980-14-4)

Guidance literature:

With potassium carbonate; copper; In pentan-1-ol; at 110 ℃;

Reference yield:

→ 5-methoxy-2-[(4-methoxyphenyl)amino]benzoic acid (56980-14-4)

Guidance literature:

entspr. Cl-Benzoesaeurederiv., entspr. Anilinderiv.;

upstream raw materials:

4-methoxy-aniline

2-bromo-5-methoxy-benzoic acid

Downstream raw materials:

2,7-Dimethoxy-9-chloroacridine

2,7-dimethoxy-9-phenoxy-acridine