2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide
• CAS No.: 3972-81-4
• Molecular Formula: C18H21NO3
• Molecular Weight: 299.37
• NSC Number: 168207
• DSSTox Substance ID: DTXSID40304918
• Nikkaji Number: J1.265.963F
• Wikidata: Q82051262
• Mol file: 3972-81-4.mol

Synonyms:2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide;3972-81-4;NSC168207;Oprea1_059025;SCHEMBL9313075;DTXSID40304918;OMRSESZLILVLQM-UHFFFAOYSA-N;STK416593;AKOS003278980;NSC-168207;AO-548/40327137;N-(3,4-Dimethoxyphenylacetyl)-2-phenylethylamine

Chemical Property of 2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide

Chemical Property:

• Vapor Pressure: 1.55E-10mmHg at 25°C
• Boiling Point: 510.4°C at 760 mmHg
• Flash Point: 262.5°C
• PSA: 47.56000
• Density: 1.109g/cm³
• LogP: 2.99610
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 299.15214353
• Heavy Atom Count: 22
• Complexity: 328

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CC(=O)NCCC2=CC=CC=C2)OC

Technology Process of 2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide

There total 7 articles about 2-(3,4-dimethoxyphenyl)-N-(2-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-<(3,4-dimethoxyphenyl)methyl>-5-phenyl-2-oxazoline (81316-50-9) → N-(β-phenylethyl)-3,4-dimethoxyphenylacetamide (3972-81-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 13h; under 2585.7 Torr;

DOI:10.1021/jo00132a001

Reference yield: 92.0%

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) + phenethylamine (64-04-0) → N-(β-phenylethyl)-3,4-dimethoxyphenylacetamide (3972-81-4)

Guidance literature:

With Fe⁽³⁺⁾-K-10 montmorillonite clay; In chloroform; for 7.5h; Heating;

DOI:10.1021/jo0204202

Reference yield: 45.0%

3,4-dimethoxyphenylacetyl chloride (10313-60-7) + phenethylamine (64-04-0) → N-(β-phenylethyl)-3,4-dimethoxyphenylacetamide (3972-81-4)

Guidance literature:

With sodium hydroxide; In water; at 0 ℃; for 1h;

upstream raw materials:

3,4-dimethoxyphenylacetyl chloride

phenethylamine

2-<(3,4-dimethoxyphenyl)methyl>-5-phenyl-2-oxazoline

(3,4-Dimethoxyphenyl)acetic acid

Downstream raw materials:

1-(3',4'-dimethoxybenzyl)-3,4-dihydroisoquinoline

N-(2-phenylethyl)-2-(3,4-dimethoxyphenyl)ethylamine

1-(3',4'-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

1-(3',4'-dimethoxybenzyl)isoquinoline

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