1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydroisoquinoline

Base Information

Chemical Name:1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydroisoquinoline
CAS No.:88422-82-6
Molecular Formula:C18H19NO2
Molecular Weight:281.34900
Hs Code.:
DSSTox Substance ID:DTXSID80547781
Wikidata:Q82426232

Synonyms:88422-82-6;1-(3,4-Dimethoxybenzyl)-3,4-dihydroisoquinoline;1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydroisoquinoline;DTXSID80547781

Suppliers and Price of 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydroisoquinoline

Chemical Property:

PSA：30.82000
LogP:2.72730
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:281.141578849
Heavy Atom Count:21
Complexity:368

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CC2=NCCC3=CC=CC=C32)OC

Technology Process of 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydroisoquinoline

There total 5 articles about 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

P₂ O₅: P₂ O₅

: 3972-81-4
N-(β-phenylethyl)-3,4-dimethoxyphenylacetamide

: 88422-82-6
1-(3',4'-dimethoxybenzyl)-3,4-dihydroisoquinoline

Guidance literature:: In dichloromethane; Hexamethyldisiloxane; water; 1,1,2,2-tetrachloroethane;

Reference yield:

: 3972-81-4
N-(β-phenylethyl)-3,4-dimethoxyphenylacetamide

: 88422-82-6
1-(3',4'-dimethoxybenzyl)-3,4-dihydroisoquinoline

Guidance literature:: With xylene; trichlorophosphate;

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 88422-82-6
1-(3',4'-dimethoxybenzyl)-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

2: P₂O₅ / toluene / Heating

With phosphorus pentoxide; In toluene; 1: Acylation / 2: Dehydration;
DOI:10.1016/S0960-894X(00)00326-7