1-[(2R,6R)-6-(hydroxymethyl)-1,4-dioxan-2-yl]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-[(2R,6R)-6-(hydroxymethyl)-1,4-dioxan-2-yl]pyrimidine-2,4(1H,3H)-dione
CAS No.:101527-68-8
Molecular Formula:C₉H₁₂N₂O₅
Molecular Weight:228.205
Hs Code.:
Mol file:101527-68-8.mol

Synonyms:1-[(2R,6R)-6-(Hydroxymethyl)-1,4-dioxan-2-yl]uracil

Suppliers and Price of 1-[(2R,6R)-6-(hydroxymethyl)-1,4-dioxan-2-yl]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 1-[(2R,6R)-6-(hydroxymethyl)-1,4-dioxan-2-yl]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Density:1.42g/cm³

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[(2R,6R)-6-(hydroxymethyl)-1,4-dioxan-2-yl]pyrimidine-2,4(1H,3H)-dione

There total 9 articles about 1-[(2R,6R)-6-(hydroxymethyl)-1,4-dioxan-2-yl]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 101527-67-7
1-(R)-<6-(R)-trityloxymethyl-1,4-dioxan-2-yl>uracil

: 101527-68-8
1-(R)-<6-(R)-hydroxymethyl-1,4-dioxan-2-yl>uracil

Guidance literature:: With acetic acid; at 100 ℃; for 0.166667h;

Reference yield: 21.0%

: 110238-03-4
3'-O-(methylsulfonyl)-2',3'-secouridine

: 101527-68-8
1-(R)-<6-(R)-hydroxymethyl-1,4-dioxan-2-yl>uracil

: 3',5'-anhydro-2',3'-secouridine

Guidance literature:: With sodium hydroxide; for 2h; Heating;
DOI:10.1002/hlca.19920750209

Reference yield:

: 101527-47-3
1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

: 101527-68-8
1-(R)-<6-(R)-hydroxymethyl-1,4-dioxan-2-yl>uracil

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / 18 h / 4 °C

2: 80 percent / Amberlyst 15, H₂O / methanol; acetonitrile / 168 h / Ambient temperature

3: 43 percent / 1N aq. NaOH / 2 h / Heating

With pyridine; sodium hydroxide; Amberlyst 15; water; In methanol; acetonitrile;
DOI:10.1002/hlca.19920750209