6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:87203-95-0
Molecular Formula:C₂₇H₃₁NO₄*ClH
Molecular Weight:470.008
Hs Code.:
DSSTox Substance ID:DTXSID701007416

Synonyms:6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride;87203-95-0;Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-((3,4-dimethoxyphenyl)methyl)-3-(4-methylphenyl)-, hydrochloride;DTXSID701007416;LS-85889;1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)

Suppliers and Price of 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

Vapor Pressure:1.64E-12mmHg at 25°C
Boiling Point:558.6°C at 760 mmHg
Flash Point:243.8°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:469.2019862
Heavy Atom Count:33
Complexity:566

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2CC3=CC(=C(C=C3C(N2)CC4=CC(=C(C=C4)OC)OC)OC)OC.Cl

Technology Process of 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 3 articles about 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 87203-95-0
6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / pyridine; toluene / 7.5 h / 60 - 70 °C

2: 1.) POCl₃, P₂O₅, 2.) NaBH₄, 5M NaOH / 1.) toluene, reflux 4 h, 2.) ethanol

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; trichlorophosphate; In pyridine; toluene;
DOI:10.1135/cccc19831447

Reference yield:

: 87203-61-0
2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethylamine hydrochloride

: 87203-95-0
6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / pyridine; toluene / 7.5 h / 60 - 70 °C

2: 1.) POCl₃, P₂O₅, 2.) NaBH₄, 5M NaOH / 1.) toluene, reflux 4 h, 2.) ethanol

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; trichlorophosphate; In pyridine; toluene;
DOI:10.1135/cccc19831447

Reference yield:

: 87203-89-2
N-<2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl>-3,4-dimethoxyphenylacetamide

: 87203-95-0
6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; trichlorophosphate; Yield given. Multistep reaction; 1.) toluene, reflux 4 h, 2.) ethanol;
DOI:10.1135/cccc19831447