2,3,10,11-Tetramethoxy-6-(4-tolyl)berbine hydrochloride hydrate

Base Information

Chemical Name:2,3,10,11-Tetramethoxy-6-(4-tolyl)berbine hydrochloride hydrate
CAS No.:87213-03-4
Molecular Formula:C₂₈H₃₁NO₄*ClH
Molecular Weight:482.019
Hs Code.:
DSSTox Substance ID:DTXSID901007424

Synonyms:2,3,10,11-Tetramethoxy-6-(4-tolyl)berbine hydrochloride hydrate;6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-6-(4-methylphenyl)-2,3,10,11-tetramethoxy-,hydrochloride, hydrate;87213-03-4;C28H31NO4.ClH.H2O;DTXSID901007424;C28-H31-N-O4.Cl-H.H2-O;LS-61251;2,3,10,11-Tetramethoxy-6-(4-methylphenyl)-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline--hydrogen chloride (1/1)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3,10,11-Tetramethoxy-6-(4-tolyl)berbine hydrochloride hydrate

Chemical Property:

Vapor Pressure:2.18E-12mmHg at 25°C
Boiling Point:555.7°C at 760 mmHg
Flash Point:149.7°C
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:481.2019862
Heavy Atom Count:34
Complexity:637

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2CC3=CC(=C(C=C3C4N2CC5=CC(=C(C=C5C4)OC)OC)OC)OC.Cl

Technology Process of 2,3,10,11-Tetramethoxy-6-(4-tolyl)berbine hydrochloride hydrate

There total 4 articles about 2,3,10,11-Tetramethoxy-6-(4-tolyl)berbine hydrochloride hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 87213-03-4
2,3,10,11-tetramethoxy-6-(4-tolyl)berbine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / pyridine; toluene / 7.5 h / 60 - 70 °C

2: 1.) POCl₃, P₂O₅, 2.) NaBH₄, 5M NaOH / 1.) toluene, reflux 4 h, 2.) ethanol

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; trichlorophosphate; In pyridine; toluene;
DOI:10.1135/cccc19831447

Reference yield:

: 87203-61-0
2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethylamine hydrochloride

: 87213-03-4
2,3,10,11-tetramethoxy-6-(4-tolyl)berbine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / pyridine; toluene / 7.5 h / 60 - 70 °C

2: 1.) POCl₃, P₂O₅, 2.) NaBH₄, 5M NaOH / 1.) toluene, reflux 4 h, 2.) ethanol

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; trichlorophosphate; In pyridine; toluene;
DOI:10.1135/cccc19831447

Reference yield:

: 87203-89-2
N-<2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl>-3,4-dimethoxyphenylacetamide

: 87213-03-4
2,3,10,11-tetramethoxy-6-(4-tolyl)berbine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) POCl₃, P₂O₅, 2.) NaBH₄, 5M NaOH / 1.) toluene, reflux 4 h, 2.) ethanol

With sodium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; trichlorophosphate;
DOI:10.1135/cccc19831447