4-Hydroxymethyl-3-[(E)-3-hydroxy-2-methyl-1-propenyl]-2,6-dimethylbenzeneethanol

Base Information

Chemical Name:4-Hydroxymethyl-3-[(E)-3-hydroxy-2-methyl-1-propenyl]-2,6-dimethylbenzeneethanol
CAS No.:75225-88-6
Molecular Formula:C15H22O3
Molecular Weight:0
Hs Code.:
Mol file:75225-88-6.mol

Synonyms:(E)-3-[3-(2-Hydroxy-ethyl)-6-hydroxymethyl-2,4-dimethyl-phenyl]-2-methyl-prop-2-en-1-ol;

Suppliers and Price of 4-Hydroxymethyl-3-[(E)-3-hydroxy-2-methyl-1-propenyl]-2,6-dimethylbenzeneethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 4-Hydroxymethyl-3-[(E)-3-hydroxy-2-methyl-1-propenyl]-2,6-dimethylbenzeneethanol

Chemical Property:

Melting Point:109 - 110 °C (methanol)
PSA：60.69000
LogP:1.72610

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 4-Hydroxymethyl-3-[(E)-3-hydroxy-2-methyl-1-propenyl]-2,6-dimethylbenzeneethanol

There total 16 articles about 4-Hydroxymethyl-3-[(E)-3-hydroxy-2-methyl-1-propenyl]-2,6-dimethylbenzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74973-59-4
methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

: 75225-88-6
cybrodol

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / LAH / diethyl ether / 2 h / Ambient temperature

2: 98 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 1 h / Ambient temperature

3: 80 percent / Mg powder, 1,2-dibromoethane / tetrahydrofuran / 1.) reflux, 2 h; 2.) 2 h, refux

4: 1.) ferric chloride, acetic anhydride; 2.) K₂CO₃ / 1.)18 h, RT; 2.) methanol, RT

With lithium aluminium tetrahydride; sodium acetate; acetic anhydride; iron(III) chloride; potassium carbonate; magnesium; ethylene dibromide; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1139/v81-311

Reference yield:

: 74973-56-1
2-(4-methoxymethyl-2,6-dimethylphenyl)ethanol

: 75225-88-6
cybrodol

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / nitromethane / 0.5 h / 0 °C

2: 95 percent / pyridinium tosylate / CH₂Cl₂ / 1 h / Ambient temperature

3: 25 percent / 1.6 M n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 1 h; 2.) RT, 5 h

4: 1.) ferric chloride, acetic anhydride; 2.) K₂CO₃ / 1.)18 h, RT; 2.) methanol, RT

With n-butyllithium; bromine; pyridinium p-toluenesulfonate; acetic anhydride; iron(III) chloride; potassium carbonate; In tetrahydrofuran; nitromethane; dichloromethane;
DOI:10.1139/v81-311

Reference yield:

: 79801-57-3
2-(3-bromo-4-methoxymethyl-2,6-dimethylphenyl)ethanol

: 75225-88-6
cybrodol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridinium tosylate / CH₂Cl₂ / 1 h / Ambient temperature

2: 25 percent / 1.6 M n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 1 h; 2.) RT, 5 h

3: 1.) ferric chloride, acetic anhydride; 2.) K₂CO₃ / 1.)18 h, RT; 2.) methanol, RT

With n-butyllithium; pyridinium p-toluenesulfonate; acetic anhydride; iron(III) chloride; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1139/v81-311