methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

Base Information

Chemical Name:methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate
CAS No.:74973-59-4
Molecular Formula:C₁₉H₂₈O₅
Molecular Weight:336.428
Hs Code.:

Synonyms:methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

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Chemical Property of methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

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Technology Process of methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

There total 8 articles about methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 107-31-3
Methyl formate

: 74973-57-2
1-bromo-3(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methoxymethyl-2,4-dimethylbenzene

: 74973-59-4
methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; 1.) -78 deg C, 50 min; 2.) 0 deg C, 16 h;
DOI:10.1139/v81-311

Reference yield:

: 74973-56-1
2-(4-methoxymethyl-2,6-dimethylphenyl)ethanol

: 74973-59-4
methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / nitromethane / 0.5 h / 0 °C

2: 95 percent / pyridinium tosylate / CH₂Cl₂ / 1 h / Ambient temperature

3: 62 percent / 1.6 M n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 50 min; 2.) 0 deg C, 16 h

With n-butyllithium; bromine; pyridinium p-toluenesulfonate; In tetrahydrofuran; nitromethane; dichloromethane;
DOI:10.1139/v81-311

Reference yield:

: 79801-57-3
2-(3-bromo-4-methoxymethyl-2,6-dimethylphenyl)ethanol

: 74973-59-4
methyl 3-(2-(tetrahydro-2H-pyran-2-yl)oxyethyl)-6-methyoxymethyl-2,4-dimethylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / pyridinium tosylate / CH₂Cl₂ / 1 h / Ambient temperature

2: 62 percent / 1.6 M n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 50 min; 2.) 0 deg C, 16 h

With n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1139/v81-311