5-chloroquinolin-8-yl acetate

Base Information

• Chemical Name: 5-chloroquinolin-8-yl acetate
• CAS No.: 10173-02-1
• Molecular Formula: C11H8 Cl N O2
• Molecular Weight: 221.643
• Mol file: 10173-02-1.mol

Synonyms:8-Quinolinol,5-chloro-, acetate (6CI,7CI); 8-Quinolinol, 5-chloro-, acetate (ester)(8CI,9CI); 5-Chloro-8-acetoxyquinoline; S 604; Silital

Chemical Property of 5-chloroquinolin-8-yl acetate

Chemical Property:

• Vapor Pressure: 3.2E-05mmHg at 25°C
• Boiling Point: 355.1°C at 760 mmHg
• Flash Point: 168.6°C
• Density: 1.332g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloroquinolin-8-yl acetate

There total 5 articles about 5-chloroquinolin-8-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

acetic anhydride (108-24-7) + 5-Chloro-8-hydroxyquinoline (130-16-5) → 5-chloroquinoline-8-yl acetate (10173-02-1)

Guidance literature:

at 20 ℃;

DOI:10.1021/acs.inorgchem.7b00653

Reference yield:

8-acetyloxyquinoline (2598-29-0) → 5-chloroquinoline-8-yl acetate (10173-02-1)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; N-benzyl-N,N,N-triethylammonium chloride; In water; at 50 ℃; for 12h; Temperature;

Reference yield:

8-quinolinol (148-24-3,24804-14-6) → 5-chloroquinoline-8-yl acetate (10173-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 5 h / Reflux

2: N-benzyl-N,N,N-triethylammonium chloride; 1,3-dichloro-5,5-dimethylhydantoin / water / 12 h / 50 °C

With 1,3-dichloro-5,5-dimethylhydantoin; N-benzyl-N,N,N-triethylammonium chloride; acetic acid; In water;

upstream raw materials:

acetic anhydride

5-Chloro-8-hydroxyquinoline

acetyl chloride

8-acetyloxyquinoline

Downstream raw materials:

5-chloro-7-iodoquinolin-8-ol

Refernces

• 1、 Wang, Yazhen,Yu, Feihu,Han, Xiao,Li, Ming,Tong, Yue,Ding, Jie,Hou, Hongwei. "From Surprising Solvothermal Reaction to Uncommon Zinc(II)-Catalyzed Aromatic C-H Activation Reaction for Direct Nitroquinoline Synthesis". supporting information. p. 5953 - 5958. Retrieved 2017/05/22.