2598-29-0

Usage

Uses

Used in Pharmaceutical Industry:
8-Acetoxyquinoline is used as an active pharmaceutical ingredient for the production of antimalarial drugs. Its antimalarial properties make it a valuable component in the development of medications that combat malaria.
Used in Antibacterial Applications:
8-Acetoxyquinoline is used as an antibacterial agent for its ability to inhibit the growth of bacteria. This application is particularly relevant in the development of treatments for bacterial infections.
Used in Antifungal Applications:
8-Acetoxyquinoline is used as an antifungal agent, leveraging its properties to combat fungal infections, making it a potential component in antifungal medications.
Used in Research and Development:
8-Acetoxyquinoline is used as a research compound for investigating its potential in treating various medical conditions, including cancer and parasitic infections. Its role in research is crucial for discovering new therapeutic applications and understanding its mechanisms of action.
Used in Industrial Applications:
8-Acetoxyquinoline is used in various industrial applications due to its chemical properties. Its versatility in different settings highlights its potential uses beyond the pharmaceutical industry.
It is important to consider the restrictions and safety measures associated with the use of 8-Acetoxyquinoline, given its toxic and hazardous properties, to ensure its applications are both effective and safe.

InChI:InChI=1/C11H9NO2/c1-8(13)14-10-6-2-4-9-5-3-7-12-11(9)10/h2-7H,1H3

Upstream product

• 148-24-3 8-quinolinol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 52793-99-4 8-hydroxy-7-phenylquinoline 
• 90179-61-6 8-quinolyloxytriphenylbismuth chloride 
• 105071-83-8 8-quinolyloxytriphenylbismuth trifluoroacetate 
• 64-19-7 acetic acid 
• 64-18-6 formic acid 
• 95-55-6 2-amino-phenol 

Downstream Products

• 78-93-3 butanone 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 14575-13-4 4-chloro-4-methyl-2-pentanone 
• 108-10-1 4-methyl-2-pentanone 
• 693-54-9 Decan-2-one 
• 111-13-7 hexyl-methyl-ketone 
• 71162-45-3 4-(3-cyclohexen-1-yl)-2-butanone 
• 74810-53-0 cis-6-octen-2-one 
• 148-24-3 8-quinolinol 
• 64-19-7 acetic acid 
• 769-59-5 3-phenyl-butan-2-one 
• 2550-26-7 4-Phenyl-2-butanone 
• 28507-33-7 quinolin-8-yl-4-methoxybenzoate 
• 92866-20-1 quinolin-8-yl 4-chlorobenzoate 

Relevant academic research and scientific papers

Phase stability and transformation of the α to ε-phase of Alq3 phosphor after thermal treatment and their photo-physical properties

In this study, we analyzed changes in the phases of aluminum tris 8–hydroxyquinoline (Alq3) after thermal treatment at different temperatures and their photo–physical properties. We prepared α–Alq3 phosphor via the co–precipitation method. Improvements in the phase purity due to stagnation of the α–phase and the transformation from α to ε–Alq3 were achieved by thermal treatment in an Ar atmosphere. The initial formation, stagnation, improvement in the phase purity, and conversion to ε–Alq3 were confirmed by X–ray diffraction (XRD) analysis. The XRD results were also validated by Fourier–transform infrared spectroscopy and Nuclear magnetic resonance spectroscopy. Ultraviolet–visible (UV–Vis) absorption spectroscopy was conducted in the presence of acidic and basic media at concentrations of 10?6 M to 10?3 M, respectively. The modifications in the UV–Vis absorption spectra indicated changes in the band gap energy (Eg) after thermal treatment. The variations in Eg for α and ε–Alq3 supported the stagnation and transformation of the phase. Photoluminescence (PL) analysis of the as–prepared α–Alq3 determined a λemi maximum at 516 nm. A minor blue shift of Δλ = 2 nm was observed as the PL intensity increased for the annealed α–Alq3. A large blue shift of Δλ = 18 nm as the PL intensity decreased was due to the change in phase from α to ε–Alq3. PL study of the α and ε–Alq3 phases in acidic solvent detected blue shifts, whereas red shifts occurred in the basic solvents due to variations in their dielectric constants. The mechanism related to the solvatochromatic effect on the shifts in PL emission was also determined in this study. Thermogravimetric analysis was employed to determine the thermal stability of the prepared phosphors.

One-pot method for preparing chloroquine chloroquine and diiodoquinoline

The method effectively solves the problems of (1) solving the problem of high isomer ratio in reaction products due to the fact that hydroxyl groups are ortho-alignment positioning groups when no guide groups are first C5 halogenated and C7 iodo, and purification difficulty is also increased. (2) The problems of poor atom economy, harsh reaction conditions, tedious aftertreatment steps and the like in first 66% steps C5 C7 C7 are effectively overcome by the method provided by the invention, and the C5-position halogenated product is 60% effectively overcome by overcoming the defects of poor atom economy, harsh reaction conditions, complicated post-treatment steps and the like in the two methods. The method has the advantages of economy of atoms, simplicity in operation, easiness in amplification and the like.

Quinolin-8-yl Formate: A New Option for Small-Scale Carbonylation Reactions in Microwave Reactors

A convenient procedure for conducting small-scale carbonylations of aryl or benzyl halides in a microwave reactor by using quinolin-8-yl formate is described. The resulting 8-acyloxyquinolines were shown to be more reactive than phenyl esters in acyl-tran

From Surprising Solvothermal Reaction to Uncommon Zinc(II)-Catalyzed Aromatic C-H Activation Reaction for Direct Nitroquinoline Synthesis

In this work, we first found a surprising solvothermal reaction for direct dinitration of quinoline derivative. To explore the application in direct nitroquinoline synthesis, this reaction was subsequently modified as an equivalent reaction in a Schlenk tube. More significantly, after a constant attempt, nitrated derivative was obtained in optimized condition with a zinc(II) sulfate catalyst, where some substrates with strong electron-withdrawing group were first nitrated by a directly catalyzed condition. This new zinc(II)-catalyzed aromatic C-H activation reaction is the first example of direct dinitration by a single catalyst, which will be a new facile and environmentally friendly strategy to access synthetically useful nitroquinoline derivative.

NMR study of O and N, O-substituted 8-quinolinol derivatives

The 1H and 13C NMR spectral study of several biologically active derivatives of 8-quinolinol have been made through extensive NMR studies including homodecoupling and 2D-NMR experiments such as COSY-45°, NOESY, and HeteroCOSY. Electron donating resonance and electron withdrawing inductive effect of several groups showed marked changes in chemical shifts of nuclei at the seventh positions of O-substituted quinolinols (2-15). Although in N-alkyl, 8-alkoxyquinolinium halides (16-21), ring A rightly showed low frequency chemical shift values. Copyright

Ruthenium(III) chloride catalyzed acylation of alcohols, phenols, and thiols in room temperature Ionic liquids

Ruthenium(III) chloride-catalyzed acylation of a variety of alcohols, phenols, and thiols was achieved in high yields under mild conditions (room temperature) in the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]). The ionic liquid and ruthenium catalyst can be recycled at least 10 times. Our system not only solves the basic problem of ruthenium catalyst reuse, but also avoids the use of volatile acetonitrile as solvent.

USE OF 3,5-DIPHENYLPYRAZOLE ANALOGUE AS ANTI-TUMOR AGENT

A growth inhibitory agent for tumor cells comprising a 3,5-diphenylpyrazole analogue represented by the general formula (1) or a pharmacologically acceptable salt thereof as the active ingredient: (1) wherein the group A represents a hydrogen atom, a carbonyl group or a sulfonyl group; the group J represents a lower alkyl group which may have a substituent or an amino group which may have a substituent; the groups G and Z independently represent a hydrogen atom, a hydroxyl group or the like; and the groups D, E, L, Q, X and Y independently represent a hydrogen atom, an aminocarbonyl group which may have a substituent, a lower alkoxycarbonyl group or the like.

Pentavalent Organobismuth Reagents. Part 2. The Phenylation of Phenols.

The phenylation of a variety of phenols by pentavalent bismuth reagents under neutral, acid and basic conditions has been investigated.Under basic conditions well defined pentavalent intermediates have been isolated and fully characterised.Their decomposition gives only ortho-C-phenylation (except in the case of a p-nitrophenol derivative).O-Phenylation is seen under neutral or acidic conditions.Another mechanism is proposed to explain this reaction with no pentavalent bismuth intermediate.