1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

Base Information

• Chemical Name: 1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
• CAS No.: 5630-11-5
• Deprecated CAS: 7661-70-3
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434
• European Community (EC) Number: 227-068-6
• DSSTox Substance ID: DTXSID20859390
• Nikkaji Number: J2.325.811K
• Wikidata: Q72480351
• Pharos Ligand ID: MXBQL72GMVNV
• Metabolomics Workbench ID: 132998
• ChEMBL ID: CHEMBL36536
• Mol file: 5630-11-5.mol

Synonyms:5630-11-5;1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline;2,3,5,6-Tetramethoxyaporphine;MLS000111916;EINECS 227-068-6;SMR000107835;(1)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline;5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline;tussiglaucin;Glaucine, dl;glaucine phosphate;ChemDiv1_020764;O,O-Dimethylisoboldine;S-(+)-Glaucine;NSC 34396;Oprea1_671613;Oprea1_787880;cid_10145;CHEMBL36536;SCHEMBL3040938;BDBM35523;HMS645P18;DTXSID20859390;HMS2270L09;EICOSANEDIOICACIDDIETHYLESTER;BBL007624;HY-N10824;MFCD00067283;STK375005;AKOS000264934;AKOS040764369;CCG-105531;VS-01695;LS-175713;CS-0636997;1,2,9,10-Tetramethoxy-6a-.alpha.-aporphine;6a.alpha.-Aporphine, 1,2,9,10-tetramethoxy-;SR-01000421456;SR-01000421456-1;1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-, (S)- #;5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6- methyl-4H-dibenzo(de,g)quinoline;4,5,15,16-tetramethoxy-10-methyl-10-azatetracyclo[7.7.1.0(2),?.0(1)(3),(1)?]heptadeca-1(16),2,4,6,13(17),14-hexaene

Chemical Property of 1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

Chemical Property:

• Vapor Pressure: 1.23E-09mmHg at 25°C
• Melting Point: 119℃
• Boiling Point: 487°Cat760mmHg
• Flash Point: 140.2°C
• PSA: 40.16000
• Density: 1.166g/cm³
• LogP: 3.41100
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 355.17835828
• Heavy Atom Count: 26
• Complexity: 489

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC

Technology Process of 1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

There total 31 articles about 1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4H-6-carbethoxy-1,2,9,10-tetramethoxy-5,6,6a,7-tetrahydrodibenzo[de,g]quinoline (124293-99-8) → (+/-)-glaucine (5630-11-5,139341-79-0,139341-81-4,872418-54-7)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride;

DOI:10.1016/S0040-4039(00)79487-1

Reference yield: 80.0%

laudanosine (1699-51-0,20412-65-1) → (+/-)-glaucine (5630-11-5,139341-79-0,139341-81-4,872418-54-7)

Guidance literature:

With cerium(IV) hydroxide; boron trifluoride diethyl etherate; trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87949-7

Reference yield: 77.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (+/-)-norglaucine (39945-40-9) → (+/-)-glaucine (5630-11-5,139341-79-0,139341-81-4,872418-54-7)

Guidance literature:

With formic acid; for 0.5h; Heating;

upstream raw materials:

(+/-)-glaucine

(R)-laudanosine

laudanosine

diazomethane

Downstream raw materials:

glaucine

(-)-(R)-glaucine

dehydroglaucine

oxoglaucine