2-Methyl-6-hydroxyfluoran

Base Information

• Chemical Name: 2-Methyl-6-hydroxyfluoran
• CAS No.: 83469-76-5
• Molecular Formula: C₂₁H₁₄O₄
• Molecular Weight: 330.34
• Hs Code.: 2932999099
• Mol file: 83469-76-5.mol

Synonyms:Fluoran,6'-hydroxy-2'-methyl- (6CI,7CI)

Chemical Property of 2-Methyl-6-hydroxyfluoran

Chemical Property:

• Boiling Point: 561.9oC at 760 mmHg
• Flash Point: 207.4oC
• PSA: 55.76000
• Density: 1.45g/cm3
• LogP: 4.26860

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-6-hydroxyfluoran

There total 7 articles about 2-Methyl-6-hydroxyfluoran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-fluorophenol (372-20-3) + 2-(2-hydroxy-5-methyl-benzoyl)-benzoic acid (5493-87-8) → C21H13FO3 (128678-41-1) + 6-Hydroxy-2-methylxanthen-9-spiro-1'-isobenzofuran-3'-one (83469-76-5)

Guidance literature:

With zinc(II) chloride; at 130 ℃; for 7h;

DOI:10.1016/0008-6215(90)84104-3

Reference yield:

p-cresol (106-44-5) + 2-(2'-chloro-4'-hydroxybenzoyl) benzoic acid (83469-74-3) → 6-Hydroxy-2-methylxanthen-9-spiro-1'-isobenzofuran-3'-one (83469-76-5)

Guidance literature:

With zinc(II) chloride; at 130 - 135 ℃; for 5h;

DOI:10.1016/0040-4020(82)80142-7

Reference yield:

phthalic anhydride (85-44-9) → 6-Hydroxy-2-methylxanthen-9-spiro-1'-isobenzofuran-3'-one (83469-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) AlCl₃; 3.) 1:1 HCl / 1.) 1,1,2,2-tetrachloroethane, AlCl₃ addn. in two parts at 90 degC, 1 h and at 100 degC, 1h; 2.) 130-140 degC, 5 h; 3.) cooling

2: 0.7 g / ZnCl₂ / 5 h / 130 - 135 °C

With hydrogenchloride; aluminium trichloride; zinc(II) chloride;

DOI:10.1016/0040-4020(82)80142-7

upstream raw materials:

p-cresol

2-(2,4-dihydroxybenzoyl)benzoic acid

2-(2'-chloro-4'-hydroxybenzoyl) benzoic acid

3-fluorophenol

Downstream raw materials:

2-Methyl-6-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid)xanthene-9-spiro-1'-isobenzofuran-3'-one