2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide
• CAS No.: 83304-16-9
• Molecular Formula: C17H19 N O2
• Molecular Weight: 269.343
• NSC Number: 114984
• DSSTox Substance ID: DTXSID60297257
• Nikkaji Number: J1.197.305A
• Wikidata: Q82038270
• Mol file: 83304-16-9.mol

Synonyms:2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide;83304-16-9;NSC114984;Oprea1_035198;Oprea1_418599;2-[4-(methyloxy)phenyl]-N-(2-phenylethyl)acetamide;DTXSID60297257;STK415651;AKOS002516231;NSC-114984;AG-690/10789028

Chemical Property of 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide

Chemical Property:

• Vapor Pressure: 7.95E-10mmHg at 25°C
• Boiling Point: 492°Cat760mmHg
• Flash Point: 251.4°C
• Density: 1.095g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 269.141578849
• Heavy Atom Count: 20
• Complexity: 279

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC(=O)NCCC2=CC=CC=C2

Technology Process of 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide

There total 6 articles about 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Methoxyphenylacetic acid (104-01-8) + phenethylamine (64-04-0) → 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide (83304-16-9)

Guidance literature:

With 4-methyl-morpholine; triazine-type dehydrocondensing polymer; In dichloromethane; at 20 ℃; for 19h;

DOI:10.1039/b501917f

Reference yield: 86.0%

benzylamine (100-46-9) + 4-methoxyphenyl-acetic chloride (4693-91-8) → 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide (83304-16-9)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃;

DOI:10.1002/hlca.19820650314

Reference yield: 53.0%

phenethylamine (64-04-0) + 4-methoxyphenyl-acetic chloride (4693-91-8) → 2-(4-methoxyphenyl)-N-(2-phenylethyl)acetamide (83304-16-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2007.01.014

upstream raw materials:

4-Methoxyphenylacetic acid

phenethylamine

benzylamine

4-methoxyphenyl-acetic chloride

Downstream raw materials:

2-(4-hydroxyphenyl)-N-phenethylacetamide

1-(4-Methoxybenzyl)-1,2,3,4-tetrahydroisochinolin

1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline