4-Methoxyphenylacetyl chloride

Base Information

• Chemical Name: 4-Methoxyphenylacetyl chloride
• CAS No.: 4693-91-8
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 29189900
• European Community (EC) Number: 922-515-8,628-979-5
• DSSTox Substance ID: DTXSID10196988
• Nikkaji Number: J813.392A
• Wikidata: Q72517487
• Mol file: 4693-91-8.mol

Synonyms:4-Methoxyphenylacetyl chloride;4693-91-8;2-(4-methoxyphenyl)acetyl chloride;4-methoxyphenylacetylchloride;Benzeneacetyl chloride, 4-methoxy-;p-Methoxyphenylacetyl chloride;(p-Methoxyphenyl)acetyl chloride;Benzenacetyl chloride, 4-methoxy-;(4-methoxy-phenyl)-acetyl chloride;4-methoxyphenylacetylchlorid;SCHEMBL226124;4-methoxybenzeneacetyl chloride;p-methoxyphenyl acetyl chloride;4-methoxyphenyl acetyl chloride;4-methoxy-benzeneacetyl chloride;(4-methoxyphenyl)acetyl chloride;DTXSID10196988;(4-methoxy-phenyl)acetyl chloride;(4-methoxyphenyl)-acetyl chloride;CXJOONIFSVSFAD-UHFFFAOYSA-N;4-methoxyphenylacetic acid chloride;STR07045;4-Methoxybenzeneacetic acid chloride;4-methoxyphenyl acetic acid chloride;4-Methoxyphenylacetyl chloride, 98%;MFCD00075474;[4-(methyloxy)phenyl]acetyl chloride;AKOS009157100;FT-0618956;D78187;J-506046;F2146-0467

Chemical Property of 4-Methoxyphenylacetyl chloride

Chemical Property:

• Appearance/Colour: colorless liquid
• Vapor Pressure: 0.00387mmHg at 25°C
• Refractive Index: n20/D 1.54(lit.)
• Boiling Point: 280.1 °C at 760 mmHg
• Flash Point: 100 °C
• PSA: 26.30000
• Density: 1.192 g/cm³
• LogP: 2.00310
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxyphenylacetyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 14-34-37
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC(=O)Cl
• Uses: 4-Methoxyphenylacetyl chloride may be used in the synthesis of:substituted spiro[4.5]decane1-(4′-hydroxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (higenamine), a cardiotonic principle of aconite root2,5-naphthyridine(R)-(+)-nor-roefractine

Technology Process of 4-Methoxyphenylacetyl chloride

There total 8 articles about 4-Methoxyphenylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Methoxyphenylacetic acid (104-01-8) → 4-methoxyphenyl-acetic chloride (4693-91-8)

Guidance literature:

With thionyl chloride; In toluene; Heating;

DOI:10.1016/j.ejmech.2005.02.011

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) + chloroacetyl chloride (79-04-9) → 4-methoxyphenyl-acetic chloride (4693-91-8)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide; at 30 ℃; for 2h; Inert atmosphere;

Reference yield:

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 4-Methoxyphenylacetic acid (104-01-8) → 4-methoxyphenyl-acetic chloride (4693-91-8)

Guidance literature:

With thionyl chloride;

upstream raw materials:

4-Methoxyphenylacetic acid

p-Methoxybenzyl bromide

p-methoxybenzylnitrile

4-Methoxybenzyl alcohol

Downstream raw materials:

N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-(4-methoxy-phenyl)-acetamide

1,4-di(4-methoxyphenyl)ethanone

N-(2-cyclohex-1-enylethyl)-2-(4-methoxyphenyl)-acetamide

(4-methoxy-phenyl)-acetic acid-(2-dimethylamino-ethyl ester)

Refernces

• 1、 Basavaiah, K.,Rao, G. Nageswara,Reddy, A. Satyanarayana,Reddy, V. Krishna. "An efficient total synthesis of a natural Penipanoid A". . . Retrieved 2022/01/14.
• 2、 Cao, Weidi,Tan, Davin,Lee, Richmond,Tan, Choon-Hong. "Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through a Bisguanidinium Silicate Ion Pair". supporting information. p. 1952 - 1955. Retrieved 2018/02/17.