3,5-DibroMo-4-hydroxyphenylacetic acid

Base Information

• Chemical Name: 3,5-DibroMo-4-hydroxyphenylacetic acid
• CAS No.: 24744-58-9
• Molecular Formula: C8H6 Br2 O3
• Molecular Weight: 309.942
• Mol file: 24744-58-9.mol

Synonyms:Aceticacid, (3,5-dibromo-4-hydroxyphenyl)- (8CI); 3,5-Dibromo-4-hydroxybenzeneaceticacid; 3,5-Dibromo-4-hydroxyphenylacetic acid; NSC 293848

Chemical Property of 3,5-DibroMo-4-hydroxyphenylacetic acid

Chemical Property:

• Vapor Pressure: 2.25E-06mmHg at 25°C
• Melting Point: 195 °C
• Boiling Point: 377.6°C at 760 mmHg
• PKA: 4.15±0.10(Predicted)
• Flash Point: 182.2°C
• PSA: 57.53000
• Density: 2.098g/cm³
• LogP: 2.54430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(3,5-Dibromo-4-hydroxyphenyl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DibroMo-4-hydroxyphenylacetic acid

There total 5 articles about 3,5-DibroMo-4-hydroxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-hydroxyphenylacetate (156-38-7) → (3,5-dibromo-4-hydroxyphenyl)acetic acid (24744-58-9)

Guidance literature:

With bromine; In acetic acid; at 15 ℃; for 96h;

DOI:10.1023/A:1012799002863

Reference yield: 50.0%

(4-hydroxy-phenyl)-acetic acid ethyl ester (17138-28-2) → (3,5-dibromo-4-hydroxyphenyl)acetic acid (24744-58-9) + 2-(3-bromo-4-hydroxyphenyl)acetic acid (38692-80-7)

Guidance literature:

(4-hydroxy-phenyl)-acetic acid ethyl ester; With Oxone; sodium bromide; In water; acetone; at 20 ℃; for 0.05h;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 14h;

With acetic acid; In tetrahydrofuran; water; pH=3 - 4;

DOI:10.1016/j.bmc.2010.09.001

Reference yield:

4-hydroxyphenylacetate (156-38-7) → 2-(4-hydroxyphenyl)acetamide (17194-82-0) + (3-bromo-4-hydroxyphenyl)acetamide (29121-26-4) + (3,5-dibromo-4-hydroxyphenyl)acetic acid (24744-58-9) + 2-(3-bromo-4-hydroxyphenyl)acetic acid (38692-80-7)

Guidance literature:

With bromine; urea; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given; 1.) AcOH, 60 h; 2.) 140 degC, 2 h;

DOI:10.1002/hlca.19840670610

upstream raw materials:

4-hydroxyphenylacetate

(4-hydroxy-phenyl)-acetic acid ethyl ester

Downstream raw materials:

3,5-dibromo-4-hydroxyphenylacetic acid methyl ester

3,5-dibromo-4-hydroxyphenylacetic acid ethyl ester

2,6-dibromo-4-hydroxy-4-hydroxycarbonylmethylcyclohexa-2,5-dien-1-one

2-(4-tert-butylbenzyl)-3-[2-(3,5-dibromo-4-hydroxyphenyl)acetamido]propyl pivalate

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