Chemical Property of 4-Hydroxyphenylacetic acid
Chemical Property:
- Appearance/Colour:white or light yellow crystalline powder
- Vapor Pressure:2.15E-05mmHg at 25°C
- Melting Point:148-151 °C(lit.)
- Refractive Index:1.4945 (estimate)
- Boiling Point:346.6 °C at 760 mmHg
- PKA:4.50±0.10(Predicted)
- Flash Point:177.6 °C
- PSA：57.53000
- Density:1.319 g/cm3
- LogP:1.01930
- Storage Temp.:Store below +30°C.
- Solubility.:50g/l
- Water Solubility.:Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water.
- XLogP3:0.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:2
- Exact Mass:152.047344113
- Heavy Atom Count:11
- Complexity:136
- Purity/Quality:
-
99% *data from raw suppliers
4-Hydroxyphenylacetic Acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Classes -> Other Aromatic Compounds
- Canonical SMILES:C1=CC(=CC=C1CC(=O)O)O
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Description
4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid.
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Uses
A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development. It is used as a reagent in the acylation of phenols and amines. It is also used for fluorometric determination of oxidative enzymes.
