ethyl N-[(4-methylphenyl)sulfonyl]tyrosinate

Base Information

• Chemical Name: ethyl N-[(4-methylphenyl)sulfonyl]tyrosinate
• CAS No.: 58559-09-4
• Molecular Formula: C18H21 N O5 S
• Molecular Weight: 363.434
• Mol file: 58559-09-4.mol

Synonyms:EthylN-(p-tosyl)tyrosinate; NSC 280836

Chemical Property of ethyl N-[(4-methylphenyl)sulfonyl]tyrosinate

Chemical Property:

• Vapor Pressure: 8.44E-13mmHg at 25°C
• Boiling Point: 552.1°Cat760mmHg
• Flash Point: 287.7°C
• Density: 1.273g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl N-[(4-methylphenyl)sulfonyl]tyrosinate

There total 4 articles about ethyl N-[(4-methylphenyl)sulfonyl]tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-tyrosine ethyl ester monohydrochloride (4089-07-0) + p-toluenesulfonyl chloride (98-59-9) → Ethyl N-(p-tosyl)tyrosinate (58559-09-4)

Guidance literature:

With sodium carbonate; In chloroform; water; at 20 ℃; for 2h;

DOI:10.1021/ol015526i

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → Ethyl N-(p-tosyl)tyrosinate (58559-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / HCl / 8 h / Heating

2: 98 percent / aq. Na₂CO₃ / CHCl₃ / 6 h / 20 °C

With hydrogenchloride; sodium carbonate; In chloroform;

DOI:10.1021/ja016030z

Reference yield:

L-tyrosine ethyl ester (949-67-7) + p-toluenesulfonyl chloride (98-59-9) → Ethyl N-(p-tosyl)tyrosinate (58559-09-4)

Guidance literature:

With chloroform;

upstream raw materials:

L-tyrosine ethyl ester

p-toluenesulfonyl chloride

L-tyrosine ethyl ester monohydrochloride

L-tyrosine

Downstream raw materials:

(S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid

(2S,5S,6S,7S,8R,10aS)-octahydro-5-[(4-methoxyphenyl)methyl]-2-methylamino-1H-7,10a-methanopyrrolo[1,2-a]azocine-6,8-diol

(2S,5S,6S,7R,8S,10aS)-2-[[(benzyloxy)carbonyl]methylamino]octahydro-6-hydroxy-5-[(4-methoxyphenyl)methyl]-1H-7,10a-methanopyrrolo[1,2-a]azocin-8-yl dibenzyl phosphate

N-{(S)-1-[(S)-1-Hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-2,8-dioxo-1-aza-spiro[4.5]deca-6,9-dien-3-yl}-4-methyl-benzenesulfonamide