N-desferriferrichrome

Base Information

Chemical Name:N-desferriferrichrome
CAS No.:34787-28-5
Molecular Formula:C₂₇H₄₅N₉O₁₂
Molecular Weight:687.707
Hs Code.:
Mol file:34787-28-5.mol

Synonyms:1,4,7,10,13,16-Hexaazacyclooctadecane,cyclic peptide deriv.;Cyclo(glycylglycylglycyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl-N5-acetyl-N5-hydroxy-L-ornithyl);Deferrichrome; Deferriferrichrome; Desferrichrome; Desferriferrichrome

Suppliers and Price of N-desferriferrichrome

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Desferrichrome
1mg
$ 608.00

TRC
Desferrichrome
10mg
$ 970.00

TRC
Desferrichrome
2mg
$ 300.00

Sigma-Aldrich
Ferrichrome Iron-free from Ustilago sphaerogena
5mg
$ 200.00

Sigma-Aldrich
Ferrichrome Iron-free from Ustilago sphaerogena
1mg
$ 58.10

Medical Isotopes, Inc.
Desferrichrome
1 mg
$ 890.00

Cayman Chemical
Ferrichrome (iron-free) ≥98%
1mg
$ 53.00

Cayman Chemical
Ferrichrome (iron-free) ≥98%
500μg
$ 33.00

Cayman Chemical
Ferrichrome (iron-free) ≥98%
5mg
$ 231.00

Biosynth Carbosynth
Desferrichrome
10 mg
$ 960.00

Total 8 raw suppliers

Chemical Property of N-desferriferrichrome

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：317.16000
Density:1.27g/cm³
LogP:-2.48790
Storage Temp.:2-8°C
Solubility.:DMSO, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Desferrichrome ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Ferrichrome is a hydroxamate siderophore produced by various fungi, including U. sphaerogena, that facilitates iron chelation and uptake by these organisms. It can be utilized as a heterologous siderophore by bacteria, including P. aeruginosa and V. parahaemolyticus. Ferrichrome (0.8 μM) inhibits proliferation of murine spleen mononuclear cells induced by concanavalin A and reduces the number of concanavalin A-stimulated CD4+ T cells expressing the IL-2 receptor. It also inhibits heme-catalyzed oxidation of LDL by hydrogen peroxide in a concentration-dependent manner.
Uses Growth-promoting iron chelator. Ferrichrome iron-free from Ustilago sphaerogena.

Technology Process of N-desferriferrichrome

There total 7 articles about N-desferriferrichrome which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 40332-33-0
cyclo(triglycyltri(N⁵-acetyl-N⁵-(benzyloxy)-L-ornithyl))

: 68802-67-5,34787-28-5
ferrichrome

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; water; for 8h; under 760 Torr; Ambient temperature;
DOI:10.1021/jo00261a019

Reference yield:

: C₃₉H₆₉N₉O₁₂

: 68802-67-5,34787-28-5
ferrichrome

Guidance literature:: With water; trifluoroacetic acid; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2012.02.033

Reference yield:

: 31972-52-8
Boc-Gly-Gly-OH

: 68802-67-5,34787-28-5
ferrichrome

Guidance literature:: Multi-step reaction with 5 steps

1: dicyclohexylcarbodiimide (DCC), N-methylmorpholine, N-hydroxysuccinimide (HOSu) / dimethylformamide / 48 h / Ambient temperature

2: 1 N NaOH / methanol / 0.25 h / 0 °C

3: 74 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride (DEC*HCl) / CH₂Cl₂; dimethylformamide / 15 h / 0 °C

4: 1.) TFA, 2.) pyridine / 1.) CH₂Cl₂, 0 deg C, 2.) DMF, 60 deg C, 48 h

5: 83 percent / H₂ / 10percent Pd-C / methanol; H₂O / 8 h / 760 Torr / Ambient temperature

With 4-methyl-morpholine; pyridine; sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00261a019