N-(1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-4-morpholineacetamide

Base Information

Chemical Name:N-(1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-4-morpholineacetamide
CAS No.:91454-32-9
Molecular Formula:C₂₂H₂₇N₃O₂
Molecular Weight:365.475
Hs Code.:
ChEMBL ID:CHEMBL18543
DSSTox Substance ID:DTXSID20919721

Synonyms:BRN 6075716;N-(1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-4-morpholineacetamide;91454-32-9;4-Morpholineacetamide, N-(1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-;CHEMBL18543;SCHEMBL11012675;DTXSID20919721;N-(2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-yl)-2-(morpholin-4-yl)ethanimidic acid

Suppliers and Price of N-(1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-4-morpholineacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-(1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-4-morpholineacetamide

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:365.21032711
Heavy Atom Count:27
Complexity:488

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CC(C2=C(C1)C(=CC=C2)NC(=O)CN3CCOCC3)C4=CC=CC=C4

Technology Process of N-(1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-4-morpholineacetamide

There total 4 articles about N-(1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinyl)-4-morpholineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110-91-8,99108-56-2
morpholine

: 4-phenyl-8-<(chloroacetyl)amino>-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 91454-32-9
4-phenyl-2-methyl-8-morpholino-acetylamino-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: In ethanol; for 5h; Heating;
DOI:10.1021/jm00157a012

Reference yield:

: 110-91-8,99108-56-2
morpholine

: petrolether

: 4-phenyl-8-chloro-acetylamino-2-methyl-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

: 110-16-7,26099-09-2
maleic acid

: 91454-32-9
4-phenyl-2-methyl-8-morpholino-acetylamino-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With sodium hydroxide; In methanol; ethanol; water;

Reference yield:

: 24526-64-5
nomifensine

: 91454-32-9
4-phenyl-2-methyl-8-morpholino-acetylamino-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃ / acetone / 0.5 h / Heating

2: benzene / Heating

With potassium carbonate; In acetone; benzene;