N-(Methoxycarbonyl)-L-tert-leucine N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-N2-[4-(2-thiazolyl)benzyl]hydrazide

Base Information

Chemical Name:N-(Methoxycarbonyl)-L-tert-leucine N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-N2-[4-(2-thiazolyl)benzyl]hydrazide
CAS No.:198904-01-7
Molecular Formula:C36H50N6O7S
Molecular Weight:710.8832
Hs Code.:

N-(Methoxycarbonyl)-L-tert-leucine N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-N2-[4-(2-thiazolyl)benzyl]hydrazide

Synonyms:

Suppliers and Price of N-(Methoxycarbonyl)-L-tert-leucine N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-N2-[4-(2-thiazolyl)benzyl]hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(Methoxycarbonyl)-L-tert-leucine N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-N2-[4-(2-thiazolyl)benzyl]hydrazide

Chemical Property:

Density:1.21g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(Methoxycarbonyl)-L-tert-leucine N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-N2-[4-(2-thiazolyl)benzyl]hydrazide

There total 7 articles about N-(Methoxycarbonyl)-L-tert-leucine N2-[2(S)-hydroxy-3(S)-[N-(methoxycarbonyl)-L-tert-leucylamino]-4-phenylbutyl]-N2-[4-(2-thiazolyl)benzyl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20859-02-3
L-tert-Leucine

: 198904-01-7
CGP 75136

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 2N aq. NaOH / dioxane / 18 h / 60 °C

2: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) DMF, 0 deg C, 20 min, 2.) DMF, overnight

With sodium hydroxide; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1021/jm970873c

Reference yield:

: 24856-58-4
1,1-dimethoxy-1-(4-bromophenyl)methane

: 198904-01-7
CGP 75136

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg, I₂, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl

2: 73 percent / ethanol / 4 h / Heating

3: 1.) NaCNBH₃, p-TsOH, 2.) aq. NaOH / 1.) THF, RT, 37 h, 2.) THF, reflux, 3.5 h

4: 74 percent / propan-2-ol / 16 h / Heating

5: HCO₂H / 4 h / Ambient temperature

6: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) DMF, 0 deg C, 20 min, 2.) DMF, overnight

With hydrogenchloride; sodium hydroxide; formic acid; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); iodine; diisobutylaluminium hydride; sodium cyanoborohydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; magnesium; N-ethyl-N,N-diisopropylamine; In ethanol; isopropyl alcohol;
DOI:10.1021/jm970873c

Reference yield:

: 198904-53-9
4-(thiazol-2-yl)-benzaldehyde

: 198904-01-7
CGP 75136

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / ethanol / 4 h / Heating

2: 1.) NaCNBH₃, p-TsOH, 2.) aq. NaOH / 1.) THF, RT, 37 h, 2.) THF, reflux, 3.5 h

3: 74 percent / propan-2-ol / 16 h / Heating

4: HCO₂H / 4 h / Ambient temperature

5: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) DMF, 0 deg C, 20 min, 2.) DMF, overnight

With sodium hydroxide; formic acid; sodium cyanoborohydride; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In ethanol; isopropyl alcohol;
DOI:10.1021/jm970873c