Romifenone

Base Information

Chemical Name:Romifenone
CAS No.:38373-83-0
Molecular Formula:C13H17NO3
Molecular Weight:235.283
Hs Code.:
UNII:672T0ES47P
DSSTox Substance ID:DTXSID40191729
Nikkaji Number:J19.644D
Wikidata:Q27264059
NCI Thesaurus Code:C72667
Metabolomics Workbench ID:155779
ChEMBL ID:CHEMBL2105316
Mol file:38373-83-0.mol

Synonyms:Romifenone;38373-83-0;Romifenone [INN];Romifenona;Romifenonum;1-(2-hydroxyphenyl)-3-morpholin-4-ylpropan-1-one;UNII-672T0ES47P;672T0ES47P;2'-Hydroxy-3-morpholinopropiophenone;SCHEMBL2109098;CHEMBL2105316;DTXSID40191729;Q27264059;1-Propanone, 1-(2-hydroxyphenyl)-3-(4-morpholinyl)-

Suppliers and Price of Romifenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ROMIFENONE 95.00%
5MG
$ 502.30

Total 3 raw suppliers

Chemical Property of Romifenone

Chemical Property:

Vapor Pressure:1.73E-06mmHg at 25°C
Boiling Point:385.3°C at 760 mmHg
Flash Point:186.8°C
PSA：49.77000
Density:1.173g/cm³
LogP:1.23510
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:235.12084340
Heavy Atom Count:17
Complexity:251

Purity/Quality:

99% ^*data from raw suppliers

ROMIFENONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CCC(=O)C2=CC=CC=C2O

Technology Process of Romifenone

There total 2 articles about Romifenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110-91-8,99108-56-2
morpholine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 38373-83-0
1-(2-hydroxy-phenyl)-3-morpholin-4-yl-propan-1-one

Guidance literature:: With C₇H₁₃N₂O₃S⁽¹⁺⁾*C₁₀H₁₅O₄S^(1-); at 25 ℃; for 0.416667h;
DOI:10.1016/j.molliq.2020.114370

Reference yield:

: 38373-83-0
1-(2-hydroxy-phenyl)-3-morpholin-4-yl-propan-1-one

Guidance literature:: Propiophenon IIb, Morpholin, Wasser;

Reference yield:

: 38373-83-0
1-(2-hydroxy-phenyl)-3-morpholin-4-yl-propan-1-one

: 108649-28-1
4-[(E)-3-Imidazol-1-yl-3-(2-isobutoxy-phenyl)-allyl]-morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, RT, 15 min

With sodium hydride; In dichloromethane;
DOI:10.1021/jm00391a014