Timefurone

Base Information

• Chemical Name: Timefurone
• CAS No.: 76301-19-4
• Molecular Formula: C₁₅H₁₄O₅S
• Molecular Weight: 306.339
• Hs Code.: 2932999099
• Mol file: 76301-19-4.mol

Synonyms:Timefurone

Chemical Property of Timefurone

Chemical Property:

• Vapor Pressure: 1.34E-09mmHg at 25°C
• Boiling Point: 486.1°C at 760 mmHg
• Flash Point: 247.8°C
• PSA: 87.11000
• Density: 1.322g/cm³
• LogP: 3.41940

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Timefurone

There total 2 articles about Timefurone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Khellin (82-02-0) → 4,9-Dimethoxy-7--5H-furo<3,2-g><1>benzopyran-5-one (76301-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / KOH / H₂O / 2 h / 75 °C / Heating

2: 1) NaOMe; 2) HCl gas / 1) toluene, reflux, 15h 2) 1 min (comparable yield with NaH instead of NaOMe)

With hydrogenchloride; potassium hydroxide; sodium methylate; In water;

DOI:10.1021/jo00200a002

Reference yield:

methylthioacetic acid ethyl ester (4455-13-4) + 5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran (484-51-5) → 4,9-Dimethoxy-7--5H-furo<3,2-g><1>benzopyran-5-one (76301-19-4)

Guidance literature:

Multistep reaction;

DOI:10.1021/jm00172a001

Reference yield:

4,9-Dimethoxy-7--5H-furo<3,2-g><1>benzopyran-5-one (76301-19-4) → Ammiol (668-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / CH₃I / CH₂Cl₂ / 72 h / Heating

2: 27 percent / KO₂ / dimethylsulfoxide / 0.5 h / Ambient temperature

With methyl iodide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jo00200a002

upstream raw materials:

methylthioacetic acid ethyl ester

5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

Khellin

Downstream raw materials:

Ammiol