2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE
• CAS No.: 3883-94-1
• Molecular Formula: C9H12ClNO2
• Molecular Weight: 201.653
• Hs Code.: 29225090
• Mol file: 3883-94-1.mol

Synonyms:Acetophenone,2-amino-4'-methoxy-, hydrochloride (7CI,8CI);Ethanone,2-amino-1-(4-methoxyphenyl)-, hydrochloride (9CI);2-Amino-1-(4-methoxyphenyl)ethanone hydrochloride;a-Amino-p-methoxyacetophenone hydrochloride;

Chemical Property of 2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: White to yellow to yellow-tan crystalline powder
• Melting Point: 190-193 °C(lit.)
• Boiling Point: 345.4 °C at 760 mmHg
• Flash Point: 162.7 °C
• PSA: 52.32000
• Density: 1.111g/cm3
• LogP: 2.33890

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-1-(4-methoxyphenyl)ethanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE

There total 18 articles about 2-AMINO-4'-METHOXYACETOPHENONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-amino-4'-methoxyacetophenone hydrochloride (3883-94-1)

Guidance literature:

2-Bromo-4'-methoxyacetophenone; With sodium diformamide; In acetonitrile; at 20 - 70 ℃; for 4h;

With hydrogenchloride; In ethanol; for 1h; Heating / reflux;

Reference yield: 97.0%

C11H11NO4 (129972-93-6) → 2-amino-4'-methoxyacetophenone hydrochloride (3883-94-1)

Guidance literature:

With hydrogenchloride; at 120 ℃; for 0.5h;

DOI:10.1055/s-1990-26959

Reference yield: 95.0%

(4-methoxy-phenacyl)-hexamethylenetetraminium; bromide (7770-25-4) → 2-amino-4'-methoxyacetophenone hydrochloride (3883-94-1)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 24h;

DOI:10.1055/a-1655-6078

upstream raw materials:

hexamethylenetetramine

2-chloro-1-(4-methoxyphenyl)ethanone

4-methoxybenzoylnitromethane

C₁₁H₁₁NO₄

Downstream raw materials:

5-(4-methoxyphenyl)-2-methyl-1,3-oxazole

5-(4-methoxy-phenyl)-2-(4-nonyloxy-phenyl)-thiazole

2-(4-decyloxy-phenyl)-5-(4-methoxy-phenyl)-thiazole

2,5-bis(4-methoxyphenyl)-1,3-thiazole

Refernces

• 1、 ?ahin, Zafer,Bender, Ceysu,Berk, Bark?n,Biltekin Kaleli, Sevde Nur,Demirayak, ?eref,Ko?o?lu Kalkan, Melike,Yurtta?, Leyla. "Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles". . p. 1841 - 1853. Retrieved 2022/01/08.
• 2、 Cheng, Maosheng,Cui, Hengxian,Jiang, Hong,Li, Song,Liu, Lei,Su, Xin,Sun, Yin,Wu, Tianxiao,Yin, Wenbo,Zhang, Yuxin,Zhao, Dongmei,Zhao, Liyu,Zheng, Yang. "Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi". . . Retrieved 2021/08/13.