5-(4-Methoxyphenyl)-2-methyloxazole

Base Information

• Chemical Name: 5-(4-Methoxyphenyl)-2-methyloxazole
• CAS No.: 69163-82-2
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• DSSTox Substance ID: DTXSID80463679
• Nikkaji Number: J509.022I
• Wikidata: Q82288670

Synonyms:5-(4-methoxyphenyl)-2-methyloxazole;69163-82-2;Oxazole, 5-(4-methoxyphenyl)-2-methyl-;SCHEMBL9863477;DTXSID80463679;MFCD30729857;5-(4-methoxyphenyl)-2-methyl-oxazole;SY314297;methyl 4-(2-methyl-1,3-oxazol-5-yl)phenyl ether

Chemical Property of 5-(4-Methoxyphenyl)-2-methyloxazole

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 189.078978594
• Heavy Atom Count: 14
• Complexity: 178

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C(O1)C2=CC=C(C=C2)OC

Technology Process of 5-(4-Methoxyphenyl)-2-methyloxazole

There total 12 articles about 5-(4-Methoxyphenyl)-2-methyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-diazo-1-(4-methoxyphenyl)ethanone (6832-17-3) + acetonitrile (75-05-8,26809-02-9) → 5-(4-methoxyphenyl)-2-methyl-1,3-oxazole (69163-82-2)

Guidance literature:

boron trifluoride diethyl etherate; In neat (no solvent); at 25 ℃;

DOI:10.1021/jo01306a023

Reference yield: 93.0%

acetonitrile (75-05-8,26809-02-9) + 4-methoxyphenylacetylen (768-60-5) → 5-(4-methoxyphenyl)-2-methyl-1,3-oxazole (69163-82-2)

Guidance literature:

With 8-methylquinoline 1-oxide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); at 60 ℃; for 3h;

DOI:10.1021/ja2029188

Reference yield: 85.0%

acetonitrile (75-05-8,26809-02-9) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 5-(4-methoxyphenyl)-2-methyl-1,3-oxazole (69163-82-2)

Guidance literature:

With trifluorormethanesulfonic acid; thallium(III) acetate; for 1.5h; Heating;

DOI:10.1016/S0040-4039(97)10362-8

upstream raw materials:

2-amino-4'-methoxyacetophenone hydrochloride

2-diazo-1-(4-methoxyphenyl)ethanone

acetonitrile

1,2,3-trimethoxybenzene

Downstream raw materials:

(E)-2-(3,4-dimethoxystyryl)-5-(4-methoxyphenyl)oxazole

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