2-(Hydroxymethyl)-4,6-dimethylphenol

Base Information

• Chemical Name: 2-(Hydroxymethyl)-4,6-dimethylphenol
• CAS No.: 4397-13-1
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.193
• UNII: KXB3SV3FYY
• Nikkaji Number: J1.010.178F
• Mol file: 4397-13-1.mol

Synonyms:2-(Hydroxymethyl)-4,6-dimethylphenol;KXB3SV3FYY;2,4-Dimethyl-6-hydroxymethylphenol;6-(hydroxymethyl)-2,4-dimethylphenol;2,4-Dimethyl-6-methylolphenol;6-Methylol-2,4-dimethylphenol;UNII-KXB3SV3FYY;2-Hydroxy-3,5-dimethylbenzenemethanol;Benzenemethanol, 2-hydroxy-3,5-dimethyl-;4397-13-1;SCHEMBL866775;2-Oxy-3,5-dimethylbenzylalkohol;MWGGRRBSDWVAEF-UHFFFAOYSA-N;2-Hydroxymethyl-4,6-dimethylphenol;2,4-dimethyl-6-(hydroxymethyl)phenol;3,5-Dimethyl-2-hydroxybenzyl alcohol;AKOS006324574;CS-0378556

Chemical Property of 2-(Hydroxymethyl)-4,6-dimethylphenol

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)CO)O)C

Technology Process of 2-(Hydroxymethyl)-4,6-dimethylphenol

There total 15 articles about 2-(Hydroxymethyl)-4,6-dimethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4-Xylenol (105-67-9) → 2-hydroxymethyl-4,6-dimethylphenol (4397-13-1)

Guidance literature:

In 1,2-dimethoxyethane; xylene; at 135 ℃; for 12h;

DOI:10.1055/s-1980-28942

Reference yield: 70.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,4-Xylenol (105-67-9) → 2-hydroxymethyl-4,6-dimethylphenol (4397-13-1)

Guidance literature:

With sodium metaborate tetrahydrate; In water; at 50 ℃;

DOI:10.1021/jacs.8b13006 DOI:10.1021/jacs.8b13006

Reference yield: 57.0%

3,5-dimethylsalicylaldehyde (24623-61-8) → 2-hydroxymethyl-4,6-dimethylphenol (4397-13-1)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1002/(SICI)1099-0690(199805)1998:5<837::AID-EJOC837>3.0.CO;2-7

upstream raw materials:

formaldehyd

sodium 2,4-dimethylphenolate

2,4-Xylenol

2-Acetoxy-2,4-dimethyl-6-formyl-cyclohexadien-(3,5)-on-⁽¹⁾

Downstream raw materials:

6,8-Dimethyl-2-phenyl-chroman

4-hydroxy-3-(2-hydroxy-3,5-dimethyl-benzyl)-coumarin

bis-(2-hydroxy-3,5-dimethyl-benzyl)-ether

2,4-dimethyl-6-[(phenylamino)methyl]phenol