N-(5-tert-butyl-4-{[(2S)-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide

Base Information

• Chemical Name: N-(5-tert-butyl-4-{[(2S)-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
• CAS No.: 263842-59-7
• Molecular Formula: C₃₃H₃₇F₃N₂O₆S₂
• Molecular Weight: 678.794

Synonyms:

Chemical Property of N-(5-tert-butyl-4-{[(2S)-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide

Chemical Property:

• Vapor Pressure: 1.94E-21mmHg at 25°C
• Boiling Point: 714.7°C at 760 mmHg
• Flash Point: 386°C
• Density: 1.39g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-tert-butyl-4-{[(2S)-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide

There total 11 articles about N-(5-tert-butyl-4-{[(2S)-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one (207736-87-6) + toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester (261709-55-1) → 5-trifluoromethyl-pyridine-2-sulfonic acid (5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-amide (263842-59-7,263842-60-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm990281p

Reference yield: 42.0%

(R)-4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one (260258-03-5) + toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester (261709-55-1) → (R)-N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methylphenyl)-2-(5-trifluoromethylpyridine)sulfonamide (263842-59-7,263842-60-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm990281p

Reference yield: 38.0%

5-trifluoromethyl-pyridin-2-ylsulfonylchloride (174485-72-4) + (S) 3-(4-Amino-2-tert-butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one (207736-06-9) → (S)-N-(5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methylphenyl)-2-(5-trifluoromethylpyridine)sulfonamide (263842-59-7,263842-60-0)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1021/jm990281p

upstream raw materials:

5-trifluoromethyl-pyridin-2-ylsulfonylchloride

(S) 3-(4-Amino-2-tert-butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

2-mercapto-5-trifluoromethylpyridine

(S)-4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 263842-59-7 N-(5-tert-butyl-4-{[(2S)-6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]-2-(1-methylethyl)-4-oxo-3,4-dihydro-2H-pyran-5-yl]sulfanyl}-2-methylphenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send