toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester

Base Information

• Chemical Name: toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester
• CAS No.: 261709-55-1
• Molecular Formula: C₂₄H₂₅F₃N₂O₄S₃
• Molecular Weight: 558.667

Synonyms:toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester

Chemical Property of toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester

Chemical Property:

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Technology Process of toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester

There total 2 articles about toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

5-trifluoromethyl-pyridin-2-ylsulfonylchloride (174485-72-4) + toluene-4-thiosulfonic acid S-(4-amino-2-tert-butyl-5-methylphenyl) ester (207737-29-9) → toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester (261709-55-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm990281p

Reference yield:

2-mercapto-5-trifluoromethylpyridine (76041-72-0) → toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester (261709-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Cl₂; H₂O / CCl₄ / 1 h / 0 °C

2: 48 percent / pyridine / CH₂Cl₂ / 20 °C

With pyridine; water; chlorine; In tetrachloromethane; dichloromethane; 1: Oxidation / 2: Sulfonylation;

DOI:10.1021/jm990281p

Reference yield: 75.0%

(S)-4-hydroxy-6-isopropyl-6-(2-phenethyl)-5,6-dihydropyran-2-one (260257-64-5) + toluene-4-thiosulfonic acid S-[2-tert-butyl-4-(5-trifluoromethyl-2-pyridinesulfonylamino)-5-methylphenyl] ester (261709-55-1) → (S)-5-trifluoromethylpyridine-2-sulfonic acid [5-tert-butyl-4-(4-hydroxy-6-isopropyl-2-oxo-6-phenethyl-5,6-dihydro-2H-pyran-3-ylsulfanyl)-2-methylphenyl]-amide (263842-78-0,263842-80-4,263842-79-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm990281p

upstream raw materials:

5-trifluoromethyl-pyridin-2-ylsulfonylchloride

toluene-4-thiosulfonic acid S-(4-amino-2-tert-butyl-5-methylphenyl) ester

2-mercapto-5-trifluoromethylpyridine

Downstream raw materials:

5-trifluoromethyl-pyridine-2-sulfonic acid (5-tert-butyl-4-{4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-2-oxo-5,6-dihydro-2H-pyran-3-ylsulfanyl}-2-methyl-phenyl)-amide

5-trifluoromethyl-pyridine-2-sulfonic acid [5-tert-butyl-4-(4-hydroxy-6-isopropyl-2-oxo-6-phenethyl-5,6-dihydro-2H-pyran-3-ylsulfanyl)-2-methyl-phenyl]-amide

(R)-5-trifluoromethylpyridine-2-sulfonic acid [5-tert-butyl-4-(4-hydroxy-6-isopropyl-2-oxo-6-phenethyl-5,6-dihydro-2H-pyran-3-ylsulfanyl)-2-methylphenyl]-amide

(S)-5-trifluoromethylpyridine-2-sulfonic acid [5-tert-butyl-4-(4-hydroxy-6-isopropyl-2-oxo-6-phenethyl-5,6-dihydro-2H-pyran-3-ylsulfanyl)-2-methylphenyl]-amide

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