E-5-(2-iodovinyl)-2'-deoxyuridine

Base Information

Chemical Name:E-5-(2-iodovinyl)-2'-deoxyuridine
CAS No.:69304-48-9
Molecular Formula:C₁₁H₁₃IN₂O₅
Molecular Weight:380.139
Hs Code.:
UNII:4WLK8JC9AR
DSSTox Substance ID:DTXSID70219364
Nikkaji Number:J59.521G,J675.558E
Wikidata:Q27260602
ChEMBL ID:CHEMBL223205

Synonyms:5-(2-iodovinyl)-2'-deoxyuridine;5-(2-iodovinyl)-2'-deoxyuridine, (E)-isomer;E-5-(2-iodovinyl)-dUrd

Suppliers and Price of E-5-(2-iodovinyl)-2'-deoxyuridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of E-5-(2-iodovinyl)-2'-deoxyuridine

Chemical Property:

Melting Point:167 - 169 °C (methanol)
PSA：104.55000
LogP:-0.41700
XLogP3:-0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:379.98692
Heavy Atom Count:19
Complexity:450

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C(OC1N2C=C(C(=O)NC2=O)C=CI)CO)O
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)/C=C/I)CO)O

Technology Process of E-5-(2-iodovinyl)-2'-deoxyuridine

There total 9 articles about E-5-(2-iodovinyl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 178179-66-3
1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-((E)-2-trimethylsilanyl-vinyl)-1H-pyrimidine-2,4-dione

: 69304-48-9,87727-68-2
(E)-5-(2-Iodovinyl)-2'-deoxyuridine

Guidance literature:: With Iodine monochloride; In acetonitrile; at 25 ℃; for 0.5h;
DOI:10.1021/jm9606406

Reference yield:

: 73456-10-7
E-5-(2-iodovinyl)-3',5'-di-O-p-toluoyl-2'-deoxyuridine

: 69304-48-9,87727-68-2
(E)-5-(2-Iodovinyl)-2'-deoxyuridine

Guidance literature:: With sodium methylate; In methanol; at 22 ℃; for 24h;
DOI:10.1039/P19810001665

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 69304-48-9,87727-68-2
(E)-5-(2-Iodovinyl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / (Ph₃P)2Pd(II)Cl₂ / acetonitrile / 16 h / 60 °C

2: 77 percent / iodine monochloride / acetonitrile / 0.5 h / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; Iodine monochloride; In acetonitrile;
DOI:10.1021/jm9606406