Technology Process of Pluviatolide
There total 12 articles about Pluviatolide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 16h;
Ambient temperature;
DOI:10.1021/jo00099a033
- Guidance literature:
-
With
perchloric acid; hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 3h;
under 760 Torr;
Ambient temperature;
DOI:10.1071/CH9822175
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / AlCl3 / CH2Cl2 / 2 h
2: 1.) n-BuLi, 2.) TMEDA / 1.) THF, hexane, -20 deg C, 90 min; -80 deg C, 2 h, 2.) -20 deg C, 16 h
3: 62 percent / NiCl2*6H2O, NaBH4, 2 N aq. KOH / tetrahydrofuran; methanol
4: 84 percent / H2 / 5percent Pd/C / ethyl acetate / 16 h / Ambient temperature
With
potassium hydroxide; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; N,N,N,N,-tetramethylethylenediamine; hydrogen; nickel dichloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00099a033
