(5-Ethylpyridin-2-yl)methanol

Base Information

• Chemical Name: (5-Ethylpyridin-2-yl)methanol
• CAS No.: 768-61-6
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60227615
• Wikidata: Q83107422
• Mol file: 768-61-6.mol

Synonyms:(5-ethylpyridin-2-yl)methanol;768-61-6;2-Pyridinemethanol, 5-ethyl-;5-Ethyl-2-pyridinemethanol;(5-ethyl-2-pyridinyl)methanol;(5-Ethyl-2-pyridyl)methanol;SCHEMBL2380517;2-hydroxymethyl-5-ethylpyridine;2-hydroxymethyl-5-ethyl pyridine;DTXSID60227615;LIRQOUKPZWQBRE-UHFFFAOYSA-N;CHEMBRDG-BB 4011741;AMY14112;MFCD08059843;AKOS006281652;AS-43806;(5-Ethylpyridin-2-yl)methanol, AldrichCPR;FT-0745590;EN300-170255;F2167-9390

Chemical Property of (5-Ethylpyridin-2-yl)methanol

Chemical Property:

• Vapor Pressure: 0.0122mmHg at 25°C
• Boiling Point: 249.3°C at 760 mmHg
• Flash Point: 104.6°C
• PSA: 33.12000
• Density: 1.061g/cm³
• LogP: 1.13630
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

NLT 98% ^*data from raw suppliers

(5-ethylpyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CN=C(C=C1)CO

Technology Process of (5-Ethylpyridin-2-yl)methanol

There total 6 articles about (5-Ethylpyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(5-ethylpyridin-2-yl)methyl acetate (21852-60-8) → 2-hydroxymethyl-5-ethyl pyridine (768-61-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 70 ℃; for 5h;

DOI:10.1016/j.jinorgbio.2014.12.015

Reference yield: 79.0%

trifluoroacetic acid 5-ethyl-pyridin-2-ylmethyl ester (1202066-70-3) → 2-hydroxymethyl-5-ethyl pyridine (768-61-6)

Guidance literature:

With water; potassium carbonate; In dichloromethane; at 20 ℃;

DOI:10.1039/b913470k

Reference yield:

→ 2-hydroxymethyl-5-ethyl pyridine (768-61-6)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01634a054

upstream raw materials:

trifluoroacetic acid 5-ethyl-pyridin-2-ylmethyl ester

(5-ethylpyridin-2-yl)methyl acetate

5-ethyl-2-methyl-pyridine

5-ethyl-2-methylpyridine-N-oxide

Downstream raw materials:

4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde

4-[1-(5-ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde

5-{4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxyethoxy]benzyl}-2,4-thiazolidinedione

rac-5-({p-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

Refernces

• 1、 Thibon, Aurore,Bartoli, Jean-Franois,Bourcier, Sophie,Banse, Frederic. "Mononuclear iron complexes relevant to nonheme iron oxygenases. Synthesis, characterizations and reactivity of Fe-Oxo and Fe-Peroxo intermediates". experimental part. p. 9587 - 9594. Retrieved 2010/03/04.
• 2、 -. "Bleach and oxidation catalyst". . . Retrieved 2008/06/13.