Coreximine

Base Information

Chemical Name:Coreximine
CAS No.:483-45-4
Molecular Formula:C19H21NO4
Molecular Weight:327.38
Hs Code.:
UNII:9T6OLW325N
Nikkaji Number:J31.895G
Wikidata:Q27273160
ChEMBL ID:CHEMBL1164087
Mol file:483-45-4.mol

Synonyms:Coreximine;483-45-4;(S)-Coreximine;(-)-Coreximine;UNII-9T6OLW325N;9T6OLW325N;(13aS)-3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,11-diol;6H-Dibenzo(a,g)quinolizine-2,11-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-, (S)-;(S)-(+)-Coreximine;(?)-Coreximine;COREXIMIN;COREXIMINE, (-)-;S-(-)-COREXIMINEINE;CHEMBL1164087;CHEBI:175178;Q27273160;13A.ALPHA.-BERBINE-2,11-DIOL, 3,10-DIMETHOXY-;(13AS)-5,8,13,13A-TETRAHYDRO-3,10-DIMETHOXY-6H-DIBENZO(A,G)QUINOLIZINE-2,11-DIOL;6H-DIBENZO(A,G)QUINOLIZINE-2,11-DIOL, 5,8,13,13A-TETRAHYDRO-3,10-DIMETHOXY-, (13AS)-

Suppliers and Price of Coreximine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Coreximine

Chemical Property:

PSA：62.16000
LogP:2.70840
Storage Temp.:Refrigerator
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:327.14705815
Heavy Atom Count:24
Complexity:447

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C3CC4=CC(=C(C=C4CN3CCC2=C1)OC)O)O
Isomeric SMILES:COC1=C(C=C2[C@@H]3CC4=CC(=C(C=C4CN3CCC2=C1)OC)O)O
Uses The S-(+)-enantiomer of Coreximine

Technology Process of Coreximine

There total 2 articles about Coreximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.9%

: 485-19-8
(+)-(S)-reticuline

: 3019-51-0,5164-93-2,13529-67-4,104597-61-7
isoboldine

: 25650-75-3
pallidine

: 483-45-4
S-(-)-coreximine

: 605-34-5,6451-72-5,6451-73-6,6507-34-2
(S)-scoulerine

Guidance literature:: With phosphate buffer; (S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide; NADPH; magnesium chloride; at 37 ℃; for 2h; rat liver microsomes;

Reference yield:

: 1699-46-3,7096-86-8
reticuline

: 485-19-8,1699-46-3,3968-19-2,7096-86-8,14752-49-9
(R)-reticuline

: 483-45-4
S-(-)-coreximine

: 605-34-5,6451-72-5,6451-73-6,6507-34-2
(S)-scoulerine

Guidance literature:: With magnesium chloride; catalase from bovine liver; In dimethyl sulfoxide; at 40 ℃; for 24h; pH=9; enantioselective reaction; Darkness; Enzymatic reaction;
DOI:10.1002/chem.201201895

Reference yield:

: 483-45-4
S-(-)-coreximine

: 89240-86-8
S-(+)-6'-methyl-N-norreticuline

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridine / 21 h / Ambient temperature

2: 5.78 g / CHCl₃ / 44 h / Heating

3: 4.67 g / H₂ / 10percent Pd/C / acetic acid / 2585.7 Torr

4: 21 percent / 80percent hydrazine / 120 h / 120 °C

With pyridine; hydrogen; hydrazine hydrate; palladium on activated charcoal; In chloroform; acetic acid;