Prazepine

Base Information

• Chemical Name: Prazepine
• CAS No.: 73-07-4
• Molecular Formula: C₁₉H₂₄N₂
• Molecular Weight: 280.413
• NSC Number: 172129
• UNII: 72O4809PU1
• DSSTox Substance ID: DTXSID00223272
• Wikipedia: Propazepine
• Wikidata: Q27266086
• NCI Thesaurus Code: C66459
• ChEMBL ID: CHEMBL2105257
• Mol file: 73-07-4.mol

Synonyms:Propazepine;Prazepine [INN];73-07-4;NSC-172129;UNII-72O4809PU1;3-(6,11-dihydrobenzo[c][1]benzazepin-5-yl)-N,N-dimethylpropan-1-amine;72O4809PU1;NSC 172129;Proazepine;Morphanthridine,6-dihydro-;SCHEMBL2109939;CHEMBL2105257;DTXSID00223272;NSC172129;5H-Dibenz[b, 6,11-dihydro-N,N-dimethyl-;Q27266086;5,6-Dihydro-5-(3-dimethylamino-propyl)-11H-dibenz[b,e]azepin;11H-Dibenz(b,e)azepine, 5,6-dihydro-N-(3-(dimethylamino)propyl)-

Chemical Property of Prazepine

Chemical Property:

• Vapor Pressure: 2.96E-07mmHg at 25°C
• Boiling Point: 419.8°C at 760 mmHg
• PKA: 9.40±0.28(Predicted)
• Flash Point: 188.7°C
• PSA: 6.48000
• Density: 1.041g/cm³
• LogP: 3.61410
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 280.193948774
• Heavy Atom Count: 21
• Complexity: 315

Purity/Quality:

99%min ^*data from raw suppliers

PRAZEPINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCN1CC2=CC=CC=C2CC3=CC=CC=C31

Technology Process of Prazepine

There total 3 articles about Prazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,11-dihydro-5H-dibenzo[b,e]azepine (449-55-8) + 3-(Dimethylamino)propyl chloride (109-54-6) → N-<3-Dimethylamino-propyl>-homoacridan (73-07-4)

Guidance literature:

With sodium amide; toluene;

Reference yield:

5,6-dihydro-6,11-dioxomorphanthridine (1143-50-6) → N-<3-Dimethylamino-propyl>-homoacridan (73-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium alanate; diethyl ether

2: sodium amide; toluene

With lithium aluminium tetrahydride; diethyl ether; sodium amide; toluene;

Reference yield:

→ N-<3-Dimethylamino-propyl>-homoacridan (73-07-4)

Guidance literature:

aus 5-<3-Dimethylamino-propyl>-6-morphanthridon, LiAlH4/ Ae., 16 h, Raumtemp.;

DOI:10.1021/jm00325a016

upstream raw materials:

6,11-dihydro-5H-dibenzo[b,e]azepine

3-(Dimethylamino)propyl chloride

5,6-dihydro-6,11-dioxomorphanthridine