Ethinodiol 17-acetate

Base Information

• Chemical Name: Ethinodiol 17-acetate
• CAS No.: 2061-46-3
• Molecular Formula: C22H30O3
• Molecular Weight: 342.47
• Mol file: 2061-46-3.mol

Synonyms:17β-Acetoxy-17α-ethinyl-4-oestren-3β-ol;Norethynodiol 17-Monoacetate;ent-17β-Acetoxy-17α-ethinyl-4-oestren-3β-ol;

Chemical Property of Ethinodiol 17-acetate

Chemical Property:

• Vapor Pressure: 4.28E-10mmHg at 25°C
• Melting Point: 161-164°C
• Boiling Point: 452.6°C at 760 mmHg
• Flash Point: 177.2°C
• PSA: 46.53000
• Density: 1.15g/cm³
• LogP: 3.85510
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Ethyl Acetate (Sligh

Purity/Quality:

99% ^*data from raw suppliers

Norethynodiol17-Monoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Norethynodiol 17-Monoacetate is a steroidal progestin and is used in the synthesis of cyclopentylpropionic ester of norethisterol acetate which works as a long-acting contraceptive.

Technology Process of Ethinodiol 17-acetate

There total 4 articles about Ethinodiol 17-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.65%

19-nor-17α-pregn-4-en-20-yne-3β,17-diol diacetate (297-76-7) → 17α-ethynyl-3β-hydroxy-17β-acetoxyestr-4-ene (2061-46-3)

Guidance literature:

With Antarctic fungus; for 288h; Microbiological reaction;

DOI:10.1016/j.steroids.2021.108832

Reference yield:

→ 17α-Ethynyl-17β-acetoxy-19-norandrost-4-en-3β-ol (2061-46-3,23944-81-2,23944-82-3,72541-10-7)

Guidance literature:

17α-Ethynyl-19-nortestosteroneacetat, LiAlH4, /BRN= 719032/;

Reference yield:

→ 17α-ethynyl-3β-hydroxy-17β-acetoxyestr-4-ene (2061-46-3)

Guidance literature:

17β-Acetoxy-17α-ethinyl-4-oestrenon-(3), Lithium-tri-tert.-butoxy-aluminiumhydrid;

upstream raw materials:

19-nor-17α-pregn-4-en-20-yne-3β,17-diol diacetate