methyl 2-[(2-amino-4-methyl-pentanoyl)amino]-3-phenyl-propanoate

Base Information

• Chemical Name: methyl 2-[(2-amino-4-methyl-pentanoyl)amino]-3-phenyl-propanoate
• CAS No.: 37885-98-6
• Molecular Formula: C₁₆H₂₄N₂O₃*ClH
• Molecular Weight: 328.839
• Mol file: 37885-98-6.mol

Synonyms:D-Leucyl-D-phenylalanine methyl ester monohydrochloride;NSC 524522

Chemical Property of methyl 2-[(2-amino-4-methyl-pentanoyl)amino]-3-phenyl-propanoate

Chemical Property:

• Vapor Pressure: 1.5E-08mmHg at 25°C
• Boiling Point: 457.4°Cat760mmHg
• Flash Point: 230.4°C
• PSA: 81.42000
• Density: 1.088g/cm³
• LogP: 3.15350

Purity/Quality:

99% ^*data from raw suppliers

METHYL-2-[(2-AMINO-4-METHYLPENTANOYL)AMINO]-3-PHENYLPROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-[(2-amino-4-methyl-pentanoyl)amino]-3-phenyl-propanoate

There total 10 articles about methyl 2-[(2-amino-4-methyl-pentanoyl)amino]-3-phenyl-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ methyl (S)-2-[(S)-2-amino-4-methylpentanamido]-3-phenylpropanoate hydrochloride (6461-07-0,37885-98-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 0.166667h;

Reference yield: 78.0%

N-[N-(2-benzoyl-2-ethoxycarbonylvinyl-1)-L-leucyl]-L-3-phenylalanine methyl ester (188783-08-6) → methyl (S)-2-[(S)-2-amino-4-methylpentanamido]-3-phenylpropanoate hydrochloride (6461-07-0,37885-98-6) + 5-phenyl-4-ethoxycarbonylpyrazole

Guidance literature:

With hydrazine hydrochloride; In methanol; for 5h; Heating;

DOI:10.1002/jhet.5570340128

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → methyl (S)-2-[(S)-2-amino-4-methylpentanamido]-3-phenylpropanoate hydrochloride (6461-07-0,37885-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / N-ethyl morpholine, isobutyl chloroformate / ethyl acetate / 1.) 1 h, -30 deg C, 2.) 1 h, room temperature

2: 1.2N HCl / acetic acid

With N-ethylmorpholine;; hydrogenchloride; isobutyl chloroformate; In acetic acid; ethyl acetate;

DOI:10.1007/BF00901826

upstream raw materials:

Z-L-Leu-D-Phe-OMe

N-[N-(2-benzoyl-2-ethoxycarbonylvinyl-1)-L-leucyl]-L-3-phenylalanine methyl ester

methyl (2S)-2-amino-3-phenylpropanoate

N-tert-butoxycarbonyl-L-leucine

Downstream raw materials:

C₃₂H₄₄N₄O₆

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE". . . Retrieved 2016/11/14.
• 2、 Nasief, Nader N.,Hangauer, David. "Influence of neighboring groups on the thermodynamics of hydrophobic binding: An added complex facet to the hydrophobic effect". . p. 2315 - 2333. Retrieved 2014/04/17.