Agmatine sulfate

Base Information

• Chemical Name: Agmatine sulfate
• CAS No.: 2482-00-0
• Molecular Formula: C5H16N4O4S
• Molecular Weight: 228.272
• Hs Code.: 29252900
• European Community (EC) Number: 219-617-3
• UNII: RU0176QL8I
• DSSTox Substance ID: DTXSID90179517
• Wikidata: Q21546999
• ChEMBL ID: CHEMBL1256618
• Mol file: 2482-00-0.mol

Synonyms:Agmatine sulfate;2482-00-0;1-(4-Aminobutyl)guanidine sulfate;1-Amino-4-guanidinobutane sulfate salt;Agmatine sulfate salt;(4-Aminobutyl)guanidinium sulphate;Agmatine sulfate;Guanidine, (4-aminobutyl)-, sulfate (1:1);Agmatine (sulfate);N-(4-Aminobutyl)guanidine sulfate salt;4-Guanidinobutylamine sulfate salt;N-(4-aMinobutyl)guanidine sulfate;MFCD00013109;UNII-RU0176QL8I;1-(4-aminobutyl)guanidine;sulfuric acid;RU0176QL8I;See A426902;(4-Aminobutyl)guanidine sulfate;2-(4-Aminobutyl)guanidine sufate;4-Aminobutyl-d8 Guanidine Sulfate;EINECS 219-617-3;909556-32-7;AI3-51851;Guanidine, N-(4-aminobutyl)-, sulfate (1:1);Argamine . sulfate;4-Guanidino-butylamine . sulfate;2-(4-Amino-1,1,2,2,3,3,4,4-octadeuteriobutyl)guanidine;SR-01000075244;C5H16N4O4S;Agmatine sulphate;1-Amino-4-guanidobutane Sulfate;Prestwick_710;2-(4-aminobutyl)guanidine,sulfuric acid;AGMATINE SULFATE [MI];SCHEMBL196302;SPECTRUM1503982;(4-Aminobutyl)guanadine sulfate;C5H14N4.H2O4S;CHEMBL1256618;1-(4-Aminobutyl)guanidinesulfate;AMY8986;DTXSID90179517;AGMATINE SULFATE [WHO-DD];PTAYFGHRDOMJGC-UHFFFAOYSA-N;HMS1922O14;HMS3260K21;4-Guanidinobutylamine sulphate salt;BCP06575;Tox21_500060;CCG-38892;NIH-11035;s4962;AKOS015856640;C5-H14-N4.H2-O4-S;CS-7509;LP00060;Agmatine sulfate salt, >=97%, powder;2-(4-aminobutyl)guanidine;NCGC00093574-01;NCGC00093574-02;NCGC00093574-03;NCGC00260745-01;AS-15375;N-(4-aminobutyl)guanidine;SY033517;HY-101238;A0310;EU-0100060;FT-0600398;A 7127;EN300-131695;A817507;Argamine sulfate;4-Guanidino-butylamine sulfate;SR-01000075244-1;SR-01000075244-5;1-(4-Aminobutyl)guanidine sulfate(Chunks or pellets);Q21546999;Z2472857139

Chemical Property of Agmatine sulfate

Chemical Property:

• Appearance/Colour: Powder
• Vapor Pressure: 0.00357mmHg at 25°C
• Melting Point: 234-238 °C(lit.)
• Boiling Point: 281.4 °C at 760 mmHg
• Flash Point: 124 °C
• PSA: 170.90000
• LogP: 1.52760
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: Soluble in water, nearly insoluble in alcohol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 228.08922618
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

99.00% ^*data from raw suppliers

Agmatine sulfate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CCN=C(N)N)CN.OS(=O)(=O)O
• Description: Agmatine sulfate is the sulfate of the Agmatine. Agmatine is an aninoguanidine that is naturally derived from the arginine. It can exert modulatory effect on many molecular targets such as neurotransmitter systems, opioid analgesia, ion channels, and nitric oxide (NO) synthesis and polyamine metabolism. It has been also found that it can reverse the pain induced from inflammation, neuropathy, and spinal cord injury. Those effects make it a potential candidate for multiple pharmacological applications in the future.
• Uses: Agmatine Sulfate is a a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine a t α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects. Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. Agmatine is a competitive inhibitor of nitric oxide synthase activity owing to mimicry of the natural NOS substrate arginine.

Technology Process of Agmatine sulfate

There total 3 articles about Agmatine sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-diaminobutane (110-60-1) → agmatine sulphate (2482-00-0)

Guidance literature:

Reference yield:

2-methylisothiourea sulphate (14527-26-5,867-44-7,147895-43-0) + 1,4-diaminobutane (110-60-1) → agmatine sulphate (2482-00-0)

Guidance literature:

Reference yield:

→ agmatine sulphate (2482-00-0)

Guidance literature:

upstream raw materials:

2-methylisothiourea sulphate

1,4-diaminobutane

Downstream raw materials:

1-(4-aminobutyl)guanidine

N-(4-aminobutyl)-N'-benzyloxycarbonyl guanidine

Refernces

• 1、 -. "Production process for a guanidine derivative containing an amido group and for a salt thereof". . . Retrieved 2008/06/13.