beta-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-N-cyclopropyl-1-deoxy-2,3-O-(1-methylethylidene)-

Base Information

• Chemical Name: beta-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-N-cyclopropyl-1-deoxy-2,3-O-(1-methylethylidene)-
• CAS No.: 58048-28-5
• Molecular Formula: C16H20N6O4
• Molecular Weight: 360.3678
• DSSTox Substance ID: DTXSID10206773
• Wikidata: Q76151091

Synonyms:BRN 0586984;beta-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-N-cyclopropyl-1-deoxy-2,3-O-(1-methylethylidene)-;58048-28-5;DTXSID10206773;LS-143755

Chemical Property of beta-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-N-cyclopropyl-1-deoxy-2,3-O-(1-methylethylidene)-

Chemical Property:

• Density: 1.85g/cm³
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 360.15460314
• Heavy Atom Count: 26
• Complexity: 587

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OC2C(O1)C(OC2C(=O)NC3CC3)N4C=NC5=C(N=CN=C54)N)C
• Isomeric SMILES: CC1(O[C@H]2[C@@H](O1)[C@@H](O[C@@H]2C(=O)NC3CC3)N4C=NC5=C(N=CN=C54)N)C

Technology Process of beta-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-N-cyclopropyl-1-deoxy-2,3-O-(1-methylethylidene)-

There total 5 articles about beta-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-N-cyclopropyl-1-deoxy-2,3-O-(1-methylethylidene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2',3'-isopropylideneadenosine-5'-carboxylic acid (19234-66-3) + Cyclopropylamine (765-30-0) → 5'-N-cyclopropyl-2',3'-O-isopropylidenecarboxamidoadenosine (58048-28-5)

Guidance literature:

With Isopropenyl chloroformate; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

DOI:10.1021/jm9804984

Reference yield:

2',3'-isopropylideneadenosine-5'-carboxylic acid (19234-66-3) → 5'-N-cyclopropyl-2',3'-O-isopropylidenecarboxamidoadenosine (58048-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C

2: dimethylformamide / 1 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm000150k

Reference yield:

(3aS,4S,6R,6aR)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 4-nitro-phenyl ester (159647-45-7) + Cyclopropylamine (765-30-0) → 5'-N-cyclopropyl-2',3'-O-isopropylidenecarboxamidoadenosine (58048-28-5)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/jm000150k

upstream raw materials:

2',3'-O-isopropylideneadenosine-5'-carbonyl chloride

Cyclopropylamine

2',3'-isopropylideneadenosine-5'-carboxylic acid

(3aS,4S,6R,6aR)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid 4-nitro-phenyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 58048-28-5 (3aS,4S,6R,6aR)-6-(6-amino-9H-purin-9-yl)-N-cyclopropyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxamide (non-preferred name)

Send

Send

Metric Ton KG G Pound L ML

Send

Send