2-Thiazolamine, 4-(4-methoxyphenyl)-5-(4-pyridinyl)-

Base Information

Chemical Name:2-Thiazolamine, 4-(4-methoxyphenyl)-5-(4-pyridinyl)-
CAS No.:97422-32-7
Molecular Formula:C₁₅H₁₃N₃OS
Molecular Weight:283.3482
Hs Code.:
DSSTox Substance ID:DTXSID60242969
Wikidata:Q83126897

Synonyms:4-(4-Methoxyphenyl)-5-(4-pyridinyl)-2-thiazolamine;2-Thiazolamine, 4-(4-methoxyphenyl)-5-(4-pyridinyl)-;2-Amino-4-(4-methoxyphenyl)-5-(4-pyridyl)-1,3-thiazole;97422-32-7;SCHEMBL6284661;DTXSID60242969;ZTZJAIKFRGLHGB-UHFFFAOYSA-N;LS-150623;[4-(4-methoxyphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine

Suppliers and Price of 2-Thiazolamine, 4-(4-methoxyphenyl)-5-(4-pyridinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 2-Thiazolamine, 4-(4-methoxyphenyl)-5-(4-pyridinyl)-

Chemical Property:

Vapor Pressure:1.16E-08mmHg at 25°C
Boiling Point:460.5°C at 760 mmHg
Flash Point:232.3°C
Density:1.275g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:283.07793322
Heavy Atom Count:20
Complexity:304

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=C(SC(=N2)N)C3=CC=NC=C3

Technology Process of 2-Thiazolamine, 4-(4-methoxyphenyl)-5-(4-pyridinyl)-

There total 6 articles about 2-Thiazolamine, 4-(4-methoxyphenyl)-5-(4-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 2-bromo-1-(4-methoxyphenyl)-2-(4-pyridyl)ethanone hydrobromide

: 17356-08-0
thiourea

: 97422-32-7
[4-(4-methoxyphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine

Guidance literature:: With triethylamine; In acetonitrile; for 3h; Heating;
DOI:10.1248/cpb.53.410

Reference yield: 68.0%

: 97422-32-7
[4-(4-methoxyphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine

Guidance literature:

Reference yield:

: 303162-29-0
(4-methoxyphenyl)(2-methylaziridin-1-yl)methanone

: 97422-32-7
[4-(4-methoxyphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 0.33 h / -10 °C

1.2: 54 percent / tetrahydrofuran; hexane / 1 h / -78 °C

2.1: 93 percent / Br₂; AcOH / 3 h / 80 °C

3.1: 68 percent / Et₃N / acetonitrile / 3 h / Heating

With bromine; acetic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1248/cpb.53.410