9-(6'-deoxytalofuranosyl)hypoxanthine

Base Information

• Chemical Name: 9-(6'-deoxytalofuranosyl)hypoxanthine
• CAS No.: 86527-20-0
• Molecular Formula: C₁₁H₁₄N₄O₅
• Molecular Weight: 282.256
• Mol file: 86527-20-0.mol

Synonyms:9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-((S)-1-hydroxy-ethyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one;

Chemical Property of 9-(6'-deoxytalofuranosyl)hypoxanthine

Chemical Property:

• Vapor Pressure: 1.06E-20mmHg at 25°C
• Boiling Point: 702.3°C at 760 mmHg
• Flash Point: 378.5°C
• PSA: 133.49000
• Density: 1.96g/cm³
• LogP: -1.88040

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(6'-deoxytalofuranosyl)hypoxanthine

There total 3 articles about 9-(6'-deoxytalofuranosyl)hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-α-L-talofuranosyl>hypoxanthine (86527-18-6) → 9-(6'-deoxy-α-L-talofuranosyl)hypoxanthine (86527-20-0)

Guidance literature:

With ammonia; for 48h;

DOI:10.1021/jm00364a032

Reference yield:

6-deoxy-2,3,5-tris-O-(p-nitrobenzoyl)-α-L-talofuranosyl bromide (80851-32-7) → 9-(6'-deoxy-α-L-talofuranosyl)hypoxanthine (86527-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent / tin tetrachloride / CH₂Cl₂ / Ambient temperature

2: 72 percent / methanolic ammonia / 48 h

With ammonia; tin(IV) chloride; In dichloromethane;

DOI:10.1021/jm00364a032

Reference yield:

O,N9-bis(trimethylsilyl)hypoxanthine (17962-89-9) → 9-(6'-deoxy-α-L-talofuranosyl)hypoxanthine (86527-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent / tin tetrachloride / CH₂Cl₂ / Ambient temperature

2: 72 percent / methanolic ammonia / 48 h

With ammonia; tin(IV) chloride; In dichloromethane;

DOI:10.1021/jm00364a032

upstream raw materials:

9-<6'-deoxy-2',3',5'-tris-O-(p-nitrobenzoyl)-α-L-talofuranosyl>hypoxanthine

6-deoxy-2,3,5-tris-O-(p-nitrobenzoyl)-α-L-talofuranosyl bromide

O,N⁹-bis(trimethylsilyl)hypoxanthine

Refernces