3-chloro-5-(4-chlorophenyl)-N-(2-morpholin-4-ium-4-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Base Information

Chemical Name:3-chloro-5-(4-chlorophenyl)-N-(2-morpholin-4-ium-4-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS No.:6748-99-8
Molecular Formula:C20H19Cl2F3N5O2+
Molecular Weight:489.2978
Hs Code.:
DSSTox Substance ID:DTXSID10410212
Wikidata:Q82216312

Synonyms:6748-99-8;3-chloro-5-(4-chlorophenyl)-N-(2-morpholin-4-ium-4-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide;DTXSID10410212

Suppliers and Price of 3-chloro-5-(4-chlorophenyl)-N-(2-morpholin-4-ium-4-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-chloro-5-(4-chlorophenyl)-N-(2-morpholin-4-ium-4-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:488.0867897
Heavy Atom Count:32
Complexity:647

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCC[NH+]1CCNC(=O)C2=NN3C(=CC(=NC3=C2Cl)C4=CC=C(C=C4)Cl)C(F)(F)F

Technology Process of 3-chloro-5-(4-chlorophenyl)-N-(2-morpholin-4-ium-4-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide

There total 49 articles about 3-chloro-5-(4-chlorophenyl)-N-(2-morpholin-4-ium-4-ylethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

: 3162-96-7
4,6-O-benzylidene-1-O-methyl-α-D-glucopyranoside

: 74-88-4
methyl iodide

: 3013-58-9,3051-89-6,4261-46-5,6748-99-8,13035-20-6,13502-46-0,22893-88-5,35311-32-1,53767-28-5,56586-53-9,56586-54-0,69744-11-2,94480-09-8,120200-48-8,120200-49-9,120200-50-2,120200-52-4
methyl 4,6-O-benzylidene-2,3-di-O-methyl-α,D-glucopyranoside

Guidance literature:: 4,6-O-benzylidene-1-O-methyl-α-D-glucopyranoside; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2017.06.008

Reference yield: 95.0%

: 3162-96-7
methyl 4,6-O-benzylidene-α-D-glucopyranoside

: 74-88-4
methyl iodide

: 3013-58-9,3051-89-6,4261-46-5,6748-99-8,13035-20-6,13502-46-0,22893-88-5,35311-32-1,53767-28-5,56586-53-9,56586-54-0,69744-11-2,94480-09-8,120200-48-8,120200-49-9,120200-50-2,120200-52-4
methyl 4,6-O-benzylidene-2,3-di-O-methyl-α-D-glucopyranoside

Guidance literature:: methyl 4,6-O-benzylidene-α-D-glucopyranoside; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1.33333h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 20.5h;
DOI:10.1021/ja402319m

Reference yield: 88.0%

: 3162-96-7
methyl 4,6-O-benzylidene-α-D-glucopyranoside

: 74-88-4
methyl iodide

: 3013-58-9,3051-89-6,4261-46-5,6748-99-8,13035-20-6,13502-46-0,22893-88-5,35311-32-1,53767-28-5,56586-53-9,56586-54-0,69744-11-2,94480-09-8,120200-48-8,120200-49-9,120200-50-2,120200-52-4
methyl 4,6-O-benzylidene-2,3-di-O-methyl-α,D-glucopyranoside

Guidance literature:: methyl 4,6-O-benzylidene-α-D-glucopyranoside; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 16h;