2-(3-((2-oxopropyl)sulfonyl)-4-n-propoxy-5-(3-hydroxypropoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrafuran

Base Information

Chemical Name:2-(3-((2-oxopropyl)sulfonyl)-4-n-propoxy-5-(3-hydroxypropoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrafuran
CAS No.:140705-10-8
Molecular Formula:C28H38 O10 S
Molecular Weight:566.67
Hs Code.:
Mol file:140705-10-8.mol

Synonyms:2-(3-((2-oxopropyl)sulfonyl)-4-n-propoxy-5-(3-hydroxypropoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrafuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-((2-oxopropyl)sulfonyl)-4-n-propoxy-5-(3-hydroxypropoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrafuran

Chemical Property:

Vapor Pressure:2.28E-22mmHg at 25°C
Boiling Point:730°Cat760mmHg
Flash Point:395.3°C
PSA：135.20000
Density:1.222g/cm³
LogP:5.29870

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(3-((2-oxopropyl)sulfonyl)-4-n-propoxy-5-(3-hydroxypropoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrafuran

There total 12 articles about 2-(3-((2-oxopropyl)sulfonyl)-4-n-propoxy-5-(3-hydroxypropoxy)phenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrafuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 134236-00-3
(-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-hydroxyphenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

: 627-18-9
1-bromo-3-propanol

: 140705-10-8
(-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

Guidance literature:: With potassium carbonate; In acetone; at 56 ℃; for 42h;
DOI:10.1021/jm00097a005

Reference yield:

: 50773-56-3
3-benzyloxy-4-hydroxybenzaldehyde

: 140705-10-8
(-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 10 steps

1: 1.3 kg / bromine, sodium acetate / acetic acid / 45 h

2: 76 percent / copper / pyridine / 16 h / 95 °C

3: 1.04 kg / K₂CO₃ / dimethylformamide / 75 °C

4: 1.45 kg / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide (ETB), triethylamine / 2 h / 90 °C

5: 65 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

6: 73 percent / lithium aluminium hydride, (S)-(-)-binaphthol / ethanol; tetrahydrofuran / 1.5 h

7: 55 percent / NaBH₄ / CH₂Cl₂; ethanol / 1 h / Ambient temperature

8: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 20 min, 2.) THF, 20 min

9: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h / 2068.6 Torr

10: 90 percent / potassium carbonate / acetone / 42 h / 56 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; bromine; (S)-[1,1']-binaphthalenyl-2,2'-diol; sodium acetate; copper; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00097a005

Reference yield:

: 4815-96-7
3-bromo-4-hydroxy-5-benzyloxybenzaldehyde

: 140705-10-8
(-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran

Guidance literature:: Multi-step reaction with 9 steps

1: 76 percent / copper / pyridine / 16 h / 95 °C

2: 1.04 kg / K₂CO₃ / dimethylformamide / 75 °C

3: 1.45 kg / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide (ETB), triethylamine / 2 h / 90 °C

4: 65 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

5: 73 percent / lithium aluminium hydride, (S)-(-)-binaphthol / ethanol; tetrahydrofuran / 1.5 h

6: 55 percent / NaBH₄ / CH₂Cl₂; ethanol / 1 h / Ambient temperature

7: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 20 min, 2.) THF, 20 min

8: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h / 2068.6 Torr

9: 90 percent / potassium carbonate / acetone / 42 h / 56 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; (S)-[1,1']-binaphthalenyl-2,2'-diol; copper; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00097a005