4815-96-7

Upstream product

• 16414-34-9 3-bromo-4,5-dihydroxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 50773-56-3 3-benzyloxy-4-hydroxybenzaldehyde 

Downstream Products

• 133239-55-1 3-(methylthio)-4-hydroxy-5-(benzyloxy)benzaldehyde 
• 134236-03-6 (-)-trans-(2S,5S)-2-<3-<((2R)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 134236-02-5 (-)-trans-(2S,5S)-2-<3-<((2S)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 134169-28-1 (-)-trans-(2S,5S)-2-<3-<((2R,S)-2-hydroxypropyl)-sulfonyl>-4-n-propyl-5-(benzyloxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 134236-06-9 (-)-trans-(2S,5S)-2-<3-<((2R)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 134169-30-5 (-)-trans-(2S,5S)-2-<3-<((2S)-2-hydroxypropyl)sulfonyl>-4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 143395-23-7 (2S,5R)-2-(3-Benzyloxy-5-methanesulfonyl-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan 
• 134186-90-6 trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran 
• 134169-29-2 3-((R)-2-Hydroxy-propane-1-sulfonyl)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-2-yl]-phenol 
• 134236-04-7 3-((S)-2-Hydroxy-propane-1-sulfonyl)-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-2-yl]-phenol 
• 143346-10-5 (R)-Methoxy-phenyl-acetic acid (R)-2-{3-benzyloxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-2-yl]-benzenesulfonyl}-1-methyl-ethyl ester 
• 143395-27-1 (R)-Methoxy-phenyl-acetic acid (S)-2-{3-benzyloxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-2-yl]-benzenesulfonyl}-1-methyl-ethyl ester 
• 134169-24-7 (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-<<<3-(dibenzyloxy)phosphoryl>oxy>propoxy>phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 134236-08-1 (-)-trans-(2S,5S)-2-<3-<(2-oxopropyl)sulfonyl>-4-n-propoxy-5-<3-(phosphonooxy)propoxy>phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 

Relevant academic research and scientific papers

New Agents of Biaryl Oxidative Coupling in Fluoro Acid Medium. VI. Application to the Synthesis of Phenolic Bisbenzocyclooctadiene Lignans

A systematic study of redox couples in fluoro acid medium has been carried out for the oxidative coupling of bisbenzocyclooctadiene lignan precursors.Tl2O3 and Re2O7 were found to be the more efficient reagents with precursors possessing methylenedioxy substituents for the former and only methoxy groups for the latter.Finally, oxidative coupling of a phenolic dibenzylbutane led to a mixture of two BBCOD's, resulting from para and ortho coupling to the phenolic group. - Keywords: Bisbenzocyclooctadienes, Biaryls, Dibenzylbutanolides, Dibenzylbutanes, Phenolic coupling.

Psammaplin A derivative as well as preparation method and application thereof

The invention provides a Psammaplin A derivative as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry, wherein the Psammaplin A derivative has a structural formula represented by a formula (I), wherein in the formula, R1, R2, R3, R4, R5 and R6 are respectively selected from any one of H, OH, OCH3, Br, 3,5-di-fluoro-benzyloxy, 2-fluoro-benzyloxy, 3-fluoro-benzyloxy, 4-cyano-benzyloxy and 4-trifluoromethyl-benzyloxy; R1 and R4 are the same or different, R2 and R5 are the same or different, and R3 and R6 are the same or different. According to the invention, a new structure and thought are provided for the design of a novel HDAC inhibitor, and the developed Psammaplin A derivative has a good anti-tumor cytotoxicity effect, and also provides an important theoretical reference for the development of HDAC-based anti-tumor drugs.

Development, Synthesis, and Biological Evaluation of (-)-trans-(2S,5S)-2--4-n-propoxy-5-(3-hydroxypropoxy)-phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a Potent Orally Active Platelet-Activating Factor (PAF) Antagonist and

(-)-trans-(2S,5S)-2--4-n-propoxy-5-(3-hydroxypropoxy)phenyl>-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (10) is one of the most potent platelet-activating factor (PAF) antagonists in vitro and in vivo developed to date.This diaryl