2'-deoxyguanosine 3',5'-diphosphate

Base Information

• Chemical Name: 2'-deoxyguanosine 3',5'-diphosphate
• CAS No.: 16174-59-7
• Molecular Formula: C₁₀H₁₅N₅O₁₀P₂
• Molecular Weight: 427.204
• Mol file: 16174-59-7.mol

Synonyms:Guanosine,2'-deoxy-, 3',5'-bis(dihydrogen phosphate) (8CI);2'-Deoxyguanosine-3',5'-diphosphate

Chemical Property of 2'-deoxyguanosine 3',5'-diphosphate

Chemical Property:

• Boiling Point: 928.8°Cat760mmHg
• Flash Point: 515.5°C
• PSA: 252.95000
• Density: 2.49g/cm³
• LogP: -1.08110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-deoxyguanosine 3',5'-diphosphate

There total 4 articles about 2'-deoxyguanosine 3',5'-diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-Deoxyguanosine (961-07-9) → 2’-deoxyguanosine-3’,5’-O-bisphosphate (16174-59-7)

Guidance literature:

With O[P(O)Cl₂]2; at -15 - -10 ℃; for 4h;

DOI:10.1021/ol990240n

Reference yield:

2'-deoxyguanosine-3'-monophosphate (6220-62-8) → 2’-deoxyguanosine-3’,5’-O-bisphosphate (16174-59-7)

Guidance literature:

With ATP; T₄ polynucleotide kinase; In various solvent(s); at 37 ℃; for 0.0833333h; pH=9.4; Further Variations:; substrate concentration; Kinetics; 32P-postlabeling protocol;

DOI:10.1021/tx0002031

Reference yield:

N-isobutyryl-2'-deoxyguanosine (68892-42-2) → 2’-deoxyguanosine-3’,5’-O-bisphosphate (16174-59-7)

Guidance literature:

With pyridine; bis(pyridinium) cyanoethylphosphate; dicyclohexyl-carbodiimide; at 20 ℃;

DOI:10.1002/em.10060

upstream raw materials:

2'-deoxyguanosine-3'-monophosphate

2'-Deoxyguanosine

N-isobutyryl-2'-deoxyguanosine

Refernces

• 1、 Goncalves,Beland,Marques. "Synthesis, characterization, and comparative 32P-postlabeling efficiencies of 2,6-dimethylaniline-DNA adducts". . p. 165 - 174. Retrieved 2001.
• 2、 Schmitz,Reetz. "Solid-phase enzymatic synthesis of oligonucleotides.". . p. 1729 - 1731. Retrieved 1999.