5-Pyrimidinecarboxamide, 2-amino-4-methoxy-N-(2-(methyl(phenylmethyl)amino)ethyl)-

Base Information

Chemical Name:5-Pyrimidinecarboxamide, 2-amino-4-methoxy-N-(2-(methyl(phenylmethyl)amino)ethyl)-
CAS No.:72412-39-6
Molecular Formula:C₁₆H₂₁N₅O₂
Molecular Weight:315.375
Hs Code.:
DSSTox Substance ID:DTXSID40222709
Wikidata:Q83101025

Synonyms:BRN 5592154;5-Pyrimidinecarboxamide, 2-amino-4-methoxy-N-(2-(methyl(phenylmethyl)amino)ethyl)-;2-Amino-4-methoxy-N-(2-(methyl(phenylmethyl)amino)ethyl)-5-pyrimidinecarboxamide;72412-39-6;SCHEMBL11501403;DTXSID40222709;LS-134758

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Chemical Property of 5-Pyrimidinecarboxamide, 2-amino-4-methoxy-N-(2-(methyl(phenylmethyl)amino)ethyl)-

Chemical Property:

Density:1.213g/cm³
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:315.16952493
Heavy Atom Count:23
Complexity:362

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CCNC(=O)C1=CN=C(N=C1OC)N)CC2=CC=CC=C2

Technology Process of 5-Pyrimidinecarboxamide, 2-amino-4-methoxy-N-(2-(methyl(phenylmethyl)amino)ethyl)-

There total 5 articles about 5-Pyrimidinecarboxamide, 2-amino-4-methoxy-N-(2-(methyl(phenylmethyl)amino)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15400-53-0
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

: 72412-39-6
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [2-(benzyl-methyl-amino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pyridine / 2 h / Heating

2: 81 percent / phosphorus oxychloride / 2 h / 60 °C

3: 95 percent / sodium / Ambient temperature

4: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In pyridine; methanol; water;

Reference yield:

: 72419-36-4
2-amino-4-methoxy-5-methoxycarbonilpyrimidine

: 72412-39-6
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [2-(benzyl-methyl-amino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 344311-74-6
2-Acetylamino-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester

: 72412-39-6
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [2-(benzyl-methyl-amino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / phosphorus oxychloride / 2 h / 60 °C

2: 95 percent / sodium / Ambient temperature

3: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

4: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In methanol; water;