Methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate

Base Information

Chemical Name:Methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate
CAS No.:104973-52-6
Molecular Formula:C₁₉H₂₃NO₆
Molecular Weight:361.395
Hs Code.:
Mol file:104973-52-6.mol

Synonyms:AK-Me6;methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate;methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate, D-Phe (S-(R*,S*-(E)))-isomer;methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate, L-Phe (R-(R*,R*-(E)))-isomer;methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate, L-Phe (S-(R*,S*-(E)))-isomer

Suppliers and Price of Methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate

Chemical Property:

Vapor Pressure:3.8E-12mmHg at 25°C
Boiling Point:550°Cat760mmHg
Flash Point:286.4°C
PSA：94.23000
Density:1.212g/cm³
LogP:1.55460
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:361.15253745
Heavy Atom Count:26
Complexity:554

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC(CC1=CC=CC=C1)C(=O)OC(C=CC(=O)OC)C2(CO2)C
Isomeric SMILES:CC(=O)N[C@H](CC1=CC=CC=C1)C(=O)O[C@H](/C=C/C(=O)OC)[C@]2(CO2)C

Technology Process of Methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate

There total 7 articles about Methyl 4-(N-acetylphenylalanyl)oxy-5,6-epoxy-5-methylhex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104840-63-3
Methyl 4-(tert-Butyldiphenylsiloxy)-5-methyl-hexa-2(E),5-dienoate

: 104973-52-6
Methyl (4R,5R,2'R)-4-(N-Acetylphenylalanyloxy)-5,6-epoxy-5-methyl-hex-2(E)-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: m-chloroperbenzoic acid

2: tetrabutylammonium fluoride

3: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

With tetrabutyl ammonium fluoride; 4-pyrrolidin-1-ylpyridine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1248/cpb.34.2668

Reference yield:

: 104855-07-4
Methyl 4(R)-(tert-Butyldiphenylsiloxy)-5,6-epoxy-5(R)-methyl-but-2(E)-enoate

: 104973-52-6
Methyl (4R,5R,2'R)-4-(N-Acetylphenylalanyloxy)-5,6-epoxy-5-methyl-hex-2(E)-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammonium fluoride

2: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

With tetrabutyl ammonium fluoride; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1248/cpb.34.2668

Reference yield:

: 2018-61-3
(S)-2-acetylamino-3-phenylpropanoic acid

: 104840-74-6
Methyl 4(R)-Hydroxy-5,6-epoxy-5(R)-methylhex-2(E)-enoate

: 104973-52-6
Methyl (4R,5R,2'R)-4-(N-Acetylphenylalanyloxy)-5,6-epoxy-5-methyl-hex-2(E)-enoate

: 104973-51-5
Methyl (4R,5R,2'S)-4-(N-Acetylphenylalanyloxy)-5,6-epoxy-5-methyl-hex-2(E)-enoate

Guidance literature:: With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction. Yields of byproduct given; 1) ethyl acetate, room temp., 2) ethyl acetate, room temp.;
DOI:10.1248/cpb.38.1451