Nocardicin D

Base Information

Chemical Name:Nocardicin D
CAS No.:61425-17-0
Molecular Formula:C23H23N3O9
Molecular Weight:485.4434
Hs Code.:
DSSTox Substance ID:DTXSID40210368
Nikkaji Number:J18.366K
Wikidata:Q27154981
Metabolomics Workbench ID:144065
Mol file:61425-17-0.mol

Synonyms:Nocardicin D;61425-17-0;Antibiotic FR 29055;BRN 3578368;FR-29055;(2R)-2-amino-4-[4-[2-[[(3S)-1-[(R)-carboxy-(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]amino]-2-oxoacetyl]phenoxy]butanoic acid;1-Azetidineacetic acid, 3-(((4-(3-amino-3-carboxypropoxy)phenyl)oxoacetyl)amino)-alpha-(4-hydroxyphenyl)-2-oxo-, (3S-(1(S*),3R*(S*)))-;CHEBI:81023;DTXSID40210368;C23H23N3O9;C23-H23-N3-O9;LS-23043;C17353;Q27154981

Suppliers and Price of Nocardicin D

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
NOCARDICIN D 95.00%
5MG
$ 4526.50

TRC
NocardicinD
100mg
$ 24750.00

Usbiological
Nocardicin D
5mg
$ 4227.00

Total 2 raw suppliers

Chemical Property of Nocardicin D

Chemical Property:

PSA：200.05000
Density:1.55g/cm³
LogP:1.38710
XLogP3:-1.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:11
Exact Mass:485.14342932
Heavy Atom Count:35
Complexity:819

Purity/Quality:

97% ^*data from raw suppliers

NOCARDICIN D 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C(=O)N1C(C2=CC=C(C=C2)O)C(=O)O)NC(=O)C(=O)C3=CC=C(C=C3)OCCC(C(=O)O)N
Isomeric SMILES:C1[C@@H](C(=O)N1[C@H](C2=CC=C(C=C2)O)C(=O)O)NC(=O)C(=O)C3=CC=C(C=C3)OCC[C@H](C(=O)O)N
Uses Nocardicin D is a β-lactam antibiotic.

Technology Process of Nocardicin D

There total 19 articles about Nocardicin D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 110207-51-7
di-tert-butyl N-(tert-butoxycarbonyl)nocardicin D

: 61425-17-0
(-)-nocardicin D

Guidance literature:: With trifluoroacetic acid; 2-hydroxyethanethiol; for 0.1h; Ambient temperature;
DOI:10.1021/ja00158a040

Reference yield:

: 111216-46-7
tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate

: 61425-17-0
(-)-nocardicin D

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / triethyl phosphite, diethyl azodicarboxylate / tetrahydrofuran / 4.5 h

2: 89 percent / 1N HCl / Pd/C / ethyl acetate; methanol; acetic acid / 44 h / 2068.6 Torr

3: 2,6-lutidine / dimethylformamide / 1 h / -20 °C

4: 62 percent / 2-mercaptoethanol, trifluoroacetic acid / 0.1 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; trifluoroacetic acid; 2-hydroxyethanethiol; diethylazodicarboxylate; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00158a040

Reference yield:

: 110207-46-0
(-)-3-N-(4,5-diphenyl-4-oxazolin-2-onyl)aminocardicinic acid tert-butyl ester

: 61425-17-0
(-)-nocardicin D

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 1N HCl / Pd/C / ethyl acetate; methanol; acetic acid / 44 h / 2068.6 Torr

2: 2,6-lutidine / dimethylformamide / 1 h / -20 °C

3: 62 percent / 2-mercaptoethanol, trifluoroacetic acid / 0.1 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; trifluoroacetic acid; 2-hydroxyethanethiol; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00158a040