(αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt

Base Information

Chemical Name:(αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt
CAS No.:88147-50-6
Molecular Formula:C₁₁H₁₁N₂O₄*Na
Molecular Weight:258.209
Hs Code.:

Synonyms:(αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt

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Chemical Property of (αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt

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Technology Process of (αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt

There total 6 articles about (αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 88147-49-3
diphenylmethyl (αR,3S)-3-azido-α--2-oxo-1-azetidineacetate

: 88147-50-6
(αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt

Guidance literature:: With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In water; ethyl acetate; for 1h;
DOI:10.1016/S0040-4020(01)92152-0

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 88147-50-6
(αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt

Guidance literature:: Multi-step reaction with 5 steps

1: MeOH/H₂O, reflux, 3 d

2: pyridine / 7 °C

3: 1.) NaN₃; 2.) N₂O₄, NaOAc / 1.) DMSO, 50 degC, overnight, 2.) CHCl₃, O degC, 1 h, room temp., 2 h

4: DBU / CH₂Cl₂ / 0.02 h / Ambient temperature

5: 100 percent / H₂, NaHCO₃ / Pd-C / H₂O; ethyl acetate / 1 h

With sodium azide; hydrogen; sodium acetate; dinitrogen tetraoxide; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)92152-0

Reference yield:

: 88147-46-0,88147-51-7,88147-52-8,88156-50-7
(3S)-α-<(p-benzyloxy)phenyl>-N-(diphenylmethyl)-3-hydroxy-2-oxo-1-azedineacetamide

: 88147-50-6
(αR,3S)-3-amino-α-(p-hydroxyphenyl)-2-oxo1-azetidine-acetic acid Na salt

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 7 °C

2: 1.) NaN₃; 2.) N₂O₄, NaOAc / 1.) DMSO, 50 degC, overnight, 2.) CHCl₃, O degC, 1 h, room temp., 2 h

3: DBU / CH₂Cl₂ / 0.02 h / Ambient temperature

4: 100 percent / H₂, NaHCO₃ / Pd-C / H₂O; ethyl acetate / 1 h

With sodium azide; hydrogen; sodium acetate; dinitrogen tetraoxide; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In pyridine; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)92152-0