6-hydroxytryptamine

Base Information

• Chemical Name: 6-hydroxytryptamine
• CAS No.: 443-31-2
• Molecular Formula: C10H12 N2 O
• Molecular Weight: 176.218
• Hs Code.: 2933990090
• Mol file: 443-31-2.mol

Synonyms:Indol-6-ol,3-(2-aminoethyl)- (8CI); 6-HT; 6-Hydroxytryptamine; Ba 2806; Tryptamine,6-hydroxy-

Chemical Property of 6-hydroxytryptamine

Chemical Property:

• Vapor Pressure: 1.63E-07mmHg at 25°C
• Melting Point: 226-227 °C (decomp)
• Boiling Point: 416.1°Cat760mmHg
• PKA: 10.13±0.40(Predicted)
• Flash Point: 205.4°C
• PSA: 62.04000
• Density: 1.288g/cm³
• LogP: 2.07500

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-aminoethyl)-1H-indol-6-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-hydroxytryptamine

There total 28 articles about 6-hydroxytryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tryptamine hydochloride (343-94-2) → 7-Hydroxytryptamine (15700-23-9) + 3-(2-aminoethyl)-1H-indol-5-ol (50-67-9) + 6-hydroxytryptamine (443-31-2) + 4-Hydroxytryptamine (570-14-9)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; ascorbic acid; Multistep reaction. Title compound not separated from byproducts; 1.) H₂O, 2.) phosphate buffer (pH= 7.2, 0.1 M), 22 deg C, 2.5 min;

Reference yield:

2-(6-hydroxy-1H-indol-3-yl)-2-oxoacetamide → 6-hydroxytryptamine (443-31-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 8h; Reflux;

Reference yield:

3-(2-Azido-ethyl)-1H-indol-6-ol → 6-hydroxytryptamine (443-31-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Yield given;

DOI:10.1016/0040-4039(96)01583-3

upstream raw materials:

2-(6-benzyloxy-indol-3-yl)-ethylamine

tryptamine hydochloride

6-Hydroxytryptamin

4-hydroxy-2-nitroaniline

Downstream raw materials:

harmol

Tetrahydroharmol

Refernces

• 1、 Cuny, Gregory D.,Ulyanova, Natalia P.,Patnaik, Debasis,Liu, Ji-Feng,Lin, Xiangjie,Auerbach, Ken,Ray, Soumya S.,Xian, Jun,Glicksman, Marcie A.,Stein, Ross L.,Higgins, Jonathan M.G.. "Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors". scheme or table. p. 2015 - 2019. Retrieved 2012/04/05.
• 2、 Gartz. "Studies on the radical hydroxylation of tryptophan and tryptamine". . p. 811 - 811. Retrieved 2007/10/02.