HARMOL

Base Information

• Chemical Name: HARMOL
• CAS No.: 487-03-6
• Molecular Formula: C12H10 N2 O
• Molecular Weight: 198.224
• Hs Code.: 2933990090
• Mol file: 487-03-6.mol

Synonyms:Harmol(6CI,7CI); NSC 72292

Chemical Property of HARMOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 231°C
• Boiling Point: 552.7°Cat760mmHg
• PKA: pKa 7.90(H2O) (Uncertain);9.47 (Uncertain);15.75 (Uncertain)
• Flash Point: 255°C
• PSA: 48.91000
• Density: 1.33g/cm³
• LogP: 2.73010
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Harmol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

Useful:

Technology Process of HARMOL

There total 15 articles about HARMOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

harmine (442-51-3) → harmol (487-03-6)

Guidance literature:

With water; hydrogen bromide; acetic acid; for 15h; Reflux; Inert atmosphere;

Reference yield: 23.0%

7-acetyloxy-1-methyl-9H-pyrido[3,4-b]indole (257938-78-6) → harmol (487-03-6) + 8-chloro-harmol + 6-chloro-harmol

Guidance literature:

With N-chloro-succinimide; at 22 ℃;

DOI:10.1002/jhet.5570400304

Reference yield:

({[Mg4(adipate)4(N,N-dimethylacetamide)(H2O)]*5(N,N-dimethylacetamide)*2methanol*4H2O}) → 3-hydroxyxanthen-9-one (3722-51-8) + harmol (487-03-6) + stilbene (588-59-0) + o-tolidin (119-93-7) + trindane (1206-79-7)

Guidance literature:

at 450 - 550 ℃;

DOI:10.1021/ja401869h

upstream raw materials:

harmine

hydrogenchloride

7-acetyloxy-1-methyl-9H-pyrido[3,4-b]indole

harmaline

Downstream raw materials:

harmane

Tetrahydroharmol

Refernces

Synthesis and isolation of bromo-β-carbolines obtained by bromination of β-carboline alkaloids

10.1002/jhet.5570380512

The study focuses on the synthesis and isolation of bromo-β-carbolines, which are derivatives of β-carboline alkaloids. The researchers used N-bromosuccinimide (NBS) as the brominating agent to induce electrophilic aromatic substitution in various β-carbolines, including nor-harmane, harmane, harmine, harmol, and 7-acetylharmol. The purpose of using these chemicals was to explore the behavior of substituted β-carbolines, prepare nitro-β-carbolines and bromo-β-carbolines, and investigate their potential use as matrices (photosensitizers) in matrix-assisted ultraviolet laser desorption/ionization time-of-flight mass spectrometry (uv-maldi-tof ms). The study also aimed to understand the effects of substituents on the acid-base properties and electronic excited states of these molecules. The researchers compared the use of NBS in solution and in solid state, and employed semiempirical AM1 and PM3 calculations to predict reactivity in terms of molecular orbital energies and charge density. The results provided insights into the regioselectivity of bromination and the influence of the β-carboline/NBS molar ratio and reaction time on product selectivity.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 487-03-6 HARMOL

Send

Send

Metric Ton KG G Pound L ML

Send

Send