Pranidipine

Base Information

• Chemical Name: Pranidipine
• CAS No.: 99522-79-9
• Molecular Formula: C25H24N2O6
• Molecular Weight: 448.475
• UNII: 9DES9QVH58
• DSSTox Substance ID: DTXSID00875518
• Nikkaji Number: J22.199F
• Wikipedia: Pranidipine
• Wikidata: Q7238365
• NCI Thesaurus Code: C73027
• ChEMBL ID: CHEMBL1096842
• Mol file: 99522-79-9.mol

Synonyms:FRC 8411;FRC-8411;methyl 3-phenyl-2-propen-1-yl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate;methyl 3-phenyl-2-propyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;OPC 13340;OPC-13340;pranidipine

Chemical Property of Pranidipine

Chemical Property:

• Appearance/Colour: yellow solid
• Vapor Pressure: 3.02E-15mmHg at 25°C
• Melting Point: 140-142 °C
• Refractive Index: 1.606
• Boiling Point: 618.9 °C at 760 mmHg
• Flash Point: 328.1 °C
• PSA: 110.45000
• Density: 1.254 g/cm³
• LogP: 5.11120
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 448.16343649
• Heavy Atom Count: 33
• Complexity: 847

Purity/Quality:

99% ^*data from raw suppliers

Pranidipine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
• Isomeric SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC/C=C/C2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
• Uses: A novel calcium channel antagonist; cardiovascular agent.

Technology Process of Pranidipine

There total 2 articles about Pranidipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-(3-nitrobenzylidene)acetoacetic acid cinnamyl ester + methyl 3-aminocrotonate (21731-17-9) → pranidipine (99522-79-9)

Guidance literature:

Reference yield:

→ pranidipine (99522-79-9)

Guidance literature:

upstream raw materials:

methyl 3-aminocrotonate

Refernces

• 1、 -. "Process for preparing novel dihydropyridine derivatives". . . Retrieved 2008/06/13.