2-Hydroxyisoquinolin-1(2H)-one

Base Information

• Chemical Name: 2-Hydroxyisoquinolin-1(2H)-one
• CAS No.: 21201-50-3
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Hs Code.: 2933790090
• Mol file: 21201-50-3.mol

Synonyms:1-Hydroxyisoquinoline 2-oxide;2-Hydroxyisocarbostyril;Isocarbostyril,2-hydroxy;N-Hydroxy-iso-carbostyril;2-hydroxy-2H-isoquinolin-1-one;1(2H)-Isoquinolinone,2-hydroxy;2-Hydroxyisoquinolin-1(2H)-one;2-Hydroxy-2H-isochinolin-1-on;

Chemical Property of 2-Hydroxyisoquinolin-1(2H)-one

Chemical Property:

• Vapor Pressure: 3.89E-05mmHg at 25°C
• Melting Point: 179.5-183 °C
• Boiling Point: 338.2°C at 760 mmHg
• PKA: 8.79±0.20(Predicted)
• Flash Point: 158.3°C
• PSA: 42.23000
• Density: 1.412g/cm³
• LogP: 1.23880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydroxyisoquinolin-1(2H)-one

There total 5 articles about 2-Hydroxyisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

isocoumarin (491-31-6) → 2-Hydroxyisocarbostyril (21201-50-3)

Guidance literature:

With hydroxylamine hydrochloride; In pyridine; for 2h; Heating; on a boiling water bath;

Reference yield: 44.0%

inden-1-one (83-33-0) → 2-Hydroxyisocarbostyril (21201-50-3) + 2-Hydroxyimino-1-indanon (80070-33-3)

Guidance literature:

With n-Butyl nitrite; sodium methylate; In diethyl ether; at 0 ℃; for 5h;

Reference yield:

2-(2-hydroxyimino-ethyl)-benzoic acid (99357-98-9) → 2-Hydroxyisocarbostyril (21201-50-3)

Guidance literature:

With chlorobenzene;

DOI:10.1021/ja01546a060

upstream raw materials:

isocoumarin

2-(2-hydroxyimino-ethyl)-benzoic acid

inden-1-one

pyridine

Downstream raw materials:

4-(toluene-4-sulfonyloxy)-isoquinolin-1-ol

1,4-dichloro-1,2-dihydrocyclobutisoquinoline

2-benzoyloxy-2H-isoquinolin-1-one

N-toluenesulfonoxy-isocarbostyril